Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Relapsed or Refractory Multiple Myeloma

PRIMARY OBJECTIVES:

I. To evaluate the efficacy (overall response rate) of single agent nab-paclitaxel (Abraxane)
(paclitaxel albumin-stabilized nanoparticle formulation) in patients with relapsed or
refractory multiple myeloma.

SECONDARY OBJECTIVES:

I. To evaluate the adverse events associated with use of single agent nab-paclitaxel
(Abraxane) in patients with relapsed or refractory multiple myeloma.

II. To evaluate overall survival, time to progression, and duration of response among
patients with relapsed or refractory multiple myeloma undergoing treatment with single agent
nab-paclitaxel (Abraxane).

OUTLINE:

Patients receive paclitaxel albumin-stabilized nanoparticle formulation intravenously (IV)
over 30 minutes on days 1, 8, and 15. Treatment repeats every 28 days for up to 12 courses in
the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3-6 months for up to 3
years.

Inclusion Criteria:

- Absolute neutrophil count >= 500/mm^3

- Platelet count >= 25000/mm^3

- Hemoglobin >= 6 g/dL

- Total bilirubin =< 2.5 X institutional upper limit of normal (ULN)

- Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) =< 5
X ULN

- Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 5 X
ULN

- Creatinine =< 3 mg/dL

- Patients with relapsed or refractory myeloma who have had >= 3 lines of prior therapy

- Measurable disease of multiple myeloma as defined by at least ONE of the following:

- Serum monoclonal protein >= 1.0 g/dL

- > 200 mg of monoclonal protein in the urine on 24 hour electrophoresis

- Serum immunoglobulin free light chain >= 10 mg/dL AND abnormal serum
immunoglobulin kappa to lambda free light chain ratio

- Ability to understand and the willingness to sign a written informed consent document

- Negative (serum) pregnancy test done =< 7 days prior to registration, for women of
childbearing potential only; NOTE: Should a woman become pregnant or suspect she is
pregnant while participating in this study, she should inform her treating physician
immediately

- Willing to return to enrolling institution (Mayo Clinic in Arizona) for follow-up and
all study treatments

Exclusion Criteria:

- Myelosuppressive therapy for myeloma =< 14 days prior to registration or those who
have not recovered from acute reversible adverse events due to agents administered >
21 days earlier

- Other concurrent chemotherapy, radiotherapy, or any ancillary therapy considered
investigational; NOTE: Bisphosphonates are allowed while on protocol treatment;
patients may be receiving stable doses of corticosteroids with a maximum dose of 10 mg
of prednisone per day if they are being given for disorders other than lymphoma such
as rheumatoid arthritis, polymyalgia rheumatica or adrenal insufficiency, or asthma

- Other active malignancy =< 3 years prior to registration; EXCEPTIONS: Non-melanotic
skin cancer or carcinoma-in-situ of the cervix; NOTE: If there is a history or prior
malignancy, they must not be receiving other specific treatment (i.e. other
investigational therapy, anti-neoplastic therapy, etc.) for their cancer

- Any of the following:

- Pregnant women or women of reproductive ability who are unwilling to use
effective contraception

- Nursing women - NOTE: breastfeeding should be discontinued if the mother is
treated with nab-paclitaxel (Abraxane®)

- Men who are unwilling to use a condom (even if they have undergone a prior
vasectomy) while having intercourse with any woman, while taking the drug and for
28 days after stopping treatment

- Other co-morbidity which would interfere with patient's ability to participate in
trial, e.g. uncontrolled infection, uncompensated heart or lung disease

- Patients with a >= grade 2 peripheral neuropathy