Early Detection of Autism Spectrum Disorder in Children
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Neurology, Psychiatric, Autism |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | December 2010 |
Rationale: Autism Spectrum Disorder (ASD) is defined by deficits in social interaction and
communication identified before the age of 3 years. Modified Checklist for Autism in
Toddlers (M-CHAT) is a sensitive tool for ASD screening in children 16-23 months. A limited
number of studies with a small number of patients have documented the developmental profile
of children with ASD during infancy. Retrospective evaluations of videotaped behavior of
children with ASD at 8 months and at 12 months identified early signs of ASD. A few studies
found early signs of ASD during infancy in siblings of autistic children. Data documenting
the age of onset and regression in ASD is controversial and limited. No large prospective
studies documented the specific developmental profile of children with ASD starting at 6
months of age. Defining a specific autistic pattern on a developmental screening test could
help identify infants at risk for ASD and improve their outcome through earlier diagnosis
and treatment. More recently, genetic tests have been shown to aid in early identification
of ASD which facilitates earlier intervention. Genetic testing among siblings of children
with autism can aid in identification of autism or other related disorders in the siblings.
PURPOSE: The purpose of this study is to learn about the early signs of autism in siblings
of children with autism spectrum disorders.
- The investigators will enroll siblings of children with ASD. Those siblings who
completed the Red Flags for Communication scale (RFC) at 6 months and/or at 12 months
and failed the RFC at 12 months will be given a genetic screening test.
- It is the investigators goal to define a specific autistic pattern on a developmental
screening test that could help identify sibling infants at risk for ASD and improve
their outcome through earlier diagnosis and treatment and to evaluate if the results of
the clinical screening test will correlate with the results of the genetic screening
test.
communication identified before the age of 3 years. Modified Checklist for Autism in
Toddlers (M-CHAT) is a sensitive tool for ASD screening in children 16-23 months. A limited
number of studies with a small number of patients have documented the developmental profile
of children with ASD during infancy. Retrospective evaluations of videotaped behavior of
children with ASD at 8 months and at 12 months identified early signs of ASD. A few studies
found early signs of ASD during infancy in siblings of autistic children. Data documenting
the age of onset and regression in ASD is controversial and limited. No large prospective
studies documented the specific developmental profile of children with ASD starting at 6
months of age. Defining a specific autistic pattern on a developmental screening test could
help identify infants at risk for ASD and improve their outcome through earlier diagnosis
and treatment. More recently, genetic tests have been shown to aid in early identification
of ASD which facilitates earlier intervention. Genetic testing among siblings of children
with autism can aid in identification of autism or other related disorders in the siblings.
PURPOSE: The purpose of this study is to learn about the early signs of autism in siblings
of children with autism spectrum disorders.
- The investigators will enroll siblings of children with ASD. Those siblings who
completed the Red Flags for Communication scale (RFC) at 6 months and/or at 12 months
and failed the RFC at 12 months will be given a genetic screening test.
- It is the investigators goal to define a specific autistic pattern on a developmental
screening test that could help identify sibling infants at risk for ASD and improve
their outcome through earlier diagnosis and treatment and to evaluate if the results of
the clinical screening test will correlate with the results of the genetic screening
test.
Inclusion Criteria:
- The subject must be a sibling of a child with a previous expert clinical diagnosis of
Autism Spectrum Disorder.
- Subjects will be included for the genetic test if he/she meets the following
criteria:
- At 12 months of age he/she failed two or more items on the RFC with at least one
failed critical item
- They have no significant known hearing, vision or motor impairment that will
impact on their ability to perform on developmental assessments
Exclusion Criteria:
- Those children who do not meet the inclusion criteria
- Those who do not speak English will be excluded from this study.
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