Study of the Efficacy and Safety of Ublituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

Inclusion Criteria:

- Relapsed or Refractory B-cell Lymphoma

- Measurable or Evaluable Disease

- Previously treated with at least one line of rituximab or a rituximab based therapy

- Patients ineligible for high dose or combination chemotherapy + stem cell transplant

- ECOG Performance Status of 0, 1 or 2

- No active or chronic infection of Hepatitis B or C and no history of HIV based on
negative serology

Exclusion Criteria:

- Prior chemotherapy, investigational therapy or radiotherapy within 3 weeks of study
entry

- Prior autologous or allogeneic stem cell transplantation within 3 months of study
entry

- History of severe hypersensitivity or anaphylaxis to prior rituximab

- Uncontrolled inter-current illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, brain metastasis, or psychiatric illness that would limit compliance with
study requirements

- Pregnant women