Effect of Omega-3-fatty Acids on Blood Levels Omega-3 Fatty Acids in Patients With Age-related Macular Degeneration

There is observational data in the current literature suggesting that the intake of foods
high in marine sources of omega-3 fatty acids, such as fish, may lower the risk of
developing age-related macular degeneration (AMD). A large prospective study is underway to
determine whether oral supplementation with 1 gram of omega-3 fatty acids is beneficial for
subjects with dry AMD. The purpose of our study is to evaluate the change in serum omega-3
index (blood level of omega-3 fatty acids) after 1 gram of omega-3 fatty acid
supplementation versus 2 grams.

Inclusion Criteria:

- Ability to provide written informed consent and comply with study assessments for the
full duration of the study.

- Have AREDS category 3 or 4 disease.

- Category 3: Many medium sized drusen or one or more large drusen in one or both eyes

- Category 4: Geographic atrophy or choroidal neovascularization in one eye.

Exclusion Criteria:

- Women of child-bearing age with positive urine pregnancy tests or desire to conceive
during the course of the study.

- Patients with a known fish allergy.

- Patients currently taking supplementation with omega-3 fatty acids and have an
omega-3 index of greater than 4%.