Efficacy and Safety of Synera in Osteoarthritis Pain
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 40 - Any |
| Updated: | 11/8/2014 |
| Start Date: | September 2013 |
| End Date: | December 2014 |
| Contact: | Julia Marks |
| Email: | julia.marks@northwestern.edu |
| Phone: | 312-503-1215 |
Efficacy and Safety of Synera in OA Pain
Knee osteoarthritis (OA) can result in significant pain and limitation of function. A
number of topical non-steroidal anti-inflammatory drugs have been shown to reduce pain in
this condition. This study examines a different topical approach, utilizing a topical
anesthetic agent, to evaluate if application of such an agent would provide relief of
exercise-induced knee pain in people with knee OA.
number of topical non-steroidal anti-inflammatory drugs have been shown to reduce pain in
this condition. This study examines a different topical approach, utilizing a topical
anesthetic agent, to evaluate if application of such an agent would provide relief of
exercise-induced knee pain in people with knee OA.
Inclusion Criteria:
1. Men and women, age 40 years and above
2. Meet American College of Rheumatology criteria for knee OA
3. Knee pain most days of the week for the past month
4. Knee pain > 5/10 after exercise intervention
5. Capable of undertaking exercise intervention
6. Stable cardiovascular function
7. Able to return for all clinic visits
8. Able to read and understand the informed consent document
Exclusion Criteria:
1. Use of a walker to ambulate or inability to ambulate
2. Other forms of arthritis
3. Other major causes of pain that could be expected to interfere with assessment of
pain during this trial, e.g., recurrent migraine, back pain, fibromyalgia
4. History of myocardial infarction
5. Blood Pressure > 140 systolic/100 diastolic
6. Scheduled for and likely to need joint replacement surgery in the next 3 months
7. Any medical condition that in the judgment of the investigator would make the
participant not suitable for the study
8. Sensitivity to lidocaine, topical or injectable analgesics/anesthetics.
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