The Impact of the Routine Aminophylline Administration Following Regadenoson Stress on SPECT Myocardial Perfusion
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/3/2014 |
| Start Date: | July 2012 |
| End Date: | December 2014 |
| Contact: | Rami Doukky, MD |
| Email: | rami_doukky@rush.edu |
| Phone: | 312-942-4655 |
The Impact of Routine Administration of Aminophylline Following Regadenoson According to the ASSUAGE Protocol on the Accuracy of Regadenoson Stress Myocardial Perfusion Imaging: A Single-Blinded Cross-Over Clinical Trial
The investigators developed a modified regadenoson nuclear stress test of the heart that
incorporates an aminophylline injection following regadenoson (The ASSUAGE protocol). The
modified (ASSUAGE) protocol has been associated with fewer side effects and was better
tolerated by patients.
This study will investigate whether the modified regadenoson stress protocol (ASSUAGE)
produces blood flow pattern to the heart similar to that of a standard regadenoson stress
protocol. In proven to be the case, the ASSUAGE protocol has the potential to be used on a
wide scale instead of the current standard protocol.
incorporates an aminophylline injection following regadenoson (The ASSUAGE protocol). The
modified (ASSUAGE) protocol has been associated with fewer side effects and was better
tolerated by patients.
This study will investigate whether the modified regadenoson stress protocol (ASSUAGE)
produces blood flow pattern to the heart similar to that of a standard regadenoson stress
protocol. In proven to be the case, the ASSUAGE protocol has the potential to be used on a
wide scale instead of the current standard protocol.
Patients who had regadenoson stress nuclear stress test of the heart will be invited to
return to undergo a modified nuclear stress using the modified (ASSUAGE) protocol. Images
from the original scan will be compared to those from the second scan to determine whether
the blood flow pattern is similar between the two scans.
return to undergo a modified nuclear stress using the modified (ASSUAGE) protocol. Images
from the original scan will be compared to those from the second scan to determine whether
the blood flow pattern is similar between the two scans.
Inclusion Criteria:
- Patients who have had a qualifying regadenoson stress myocardial perfusion imaging
(regadenoson nuclear stress test).
Exclusion Criteria:
- inability to provide an informed consent
- known allergic reaction to aminophylline or regadenoson
- systolic blood pressure < 90 mmHg
- unstable abnormal heart rhythm
- pulmonary edema
- acute coronary symptoms, myocardial infarction within 48 hours
- active dipyridamole, aminophylline or theophylline use
- pregnancy
- any contraindication to aminophylline according to the drug's package insert:
uncontrolled seizure disorder, sepsis with multi-organ failure and liver impairment
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