Negative Pressure Therapy in Preventing Infection After Surgery in Patients With Colon, Rectal, Pancreatic, or Peritoneal Surface Cancer

PRIMARY OBJECTIVES:

I. To determine whether negative pressure therapy applied to closed laparotomy incisions can
decrease the incidence of incisional surgical site infections in patients undergoing
clean-contaminated resections for colorectal, pancreatic, and peritoneal surface malignancies
compared to standard post-operative sterile gauze dressings.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive standard sterile dressing (SSD) over their closed laparotomy incision
at the conclusion of their surgery.

ARM II: Patients receive negative pressure therapy (NPT) dressing over their closed
laparotomy incision at the conclusion of their surgery.

After completion of study treatment, patients are followed up at 30 days.

Inclusion Criteria:

- Surgical resection for a colorectal, pancreatic, or peritoneal surface malignancy

- The scheduled procedure will be performed via midline laparotomy

- The planned procedure is a clean-contaminated (class II) case (includes gastric, small
bowel, and colorectal resections, as well as bile or pancreatic duct transections)

- Ability to understand and the willingness to sign a written informed consent document
(either directly or via a legally authorized representative)

Exclusion Criteria:

- Emergent cases will not be included in the study

- Pregnant patients will not be included in the study as pregnancy is a relative
contraindication for these types of surgical procedures

- Clean (class I), contaminated (class III) and dirty (class IV) procedures will
likewise be excluded

- Patients on chronic immunosuppressive medications, including steroids, within the past
three months

- Patients with a history of skin allergy to iodine or adhesive drapes

- The planned procedure involves foreign material (such as mesh or subcutaneous drains)
being left in the subcutaneous space at the time of surgery (for example, a ventral
hernia repair); surgical drains that are placed to drain an intraabdominal space and
exit the abdominal wall remote from the incision are allowed in the study