The Effect of Calorie Deprivation on Adipose Tissue Distribution



Status:Active, not recruiting
Conditions:Healthy Studies
Therapuetic Areas:Other
Healthy:No
Age Range:21 - 45
Updated:4/21/2016
Start Date:September 2012
End Date:April 2016

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria
In this study, we will be studying the effects of acute calorie deprivation (a 10-day fast)
on bone marrow fat, other fat stores and bone parameters. We will be measuring changes in
bone marrow fat using magnetic resonance spectroscopy and will use MRI to measure
subcutaneous and visceral fat depots. Our hypothesis is that levels of bone marrow fat will
increase after an acute fast.


Inclusion Criteria:

- Men and women, ages 21-45 years

- 101-130% of ideal body weight as defined by the 1983 Metropolitan Life Insurance
Height and Weight Tables

- Normal thyroid function

- Regular menses (women)

- Normal liver transaminases

Exclusion Criteria:

- Any disease known to affect bone metabolism, including untreated thyroid dysfunction,
Cushing's syndrome, or renal failure

- Any medication known to affect bone metabolism -- including systemic steroids or
immunosuppressants -- within three months of the study, excluding estrogen and
progestins. Patients receiving depot medroxyprogesterone (Depo-Provera) will be
excluded from participating for six months after their last injections.
Bisphosphonates must have been discontinued for at least one year before
participation

- Serum potassium <3.0 meq/L

- Pregnant and/or breastfeeding (women)

- Diabetes mellitus

- Active substance abuse, including alcohol

- Contraindications to MRI: cardiac pacemaker, metal implants, claustrophobia
We found this trial at
1
site
Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
?
mi
from
Boston, MA
Click here to add this to my saved trials