Enhanced External Counterpulsation and Its Effects on Vascular Hemodynamics in Cognitively Impaired Patients

Inclusion Criteria:

- An adult between 18 and 85 years of age.

- Has been evaluated to have a CDR (Clinical Dementia Rating) Score of 0.5

- Male or female (if female must be postmenopausal for at least 1 year, surgically
sterile or using an effective form of contraception).

- Able to speak and read English.

- Willing to comply with study specific instructions, and complete all study procedures
according to protocol.

- Able to understand study rationale and sign informed consent.

Exclusion Criteria:

- Diagnosed with glaucoma

- History of developing adverse effects to ophthalmic dilating agents (phenylephrine or
tropicamide).

- Currently taking warfarin and dabigatran (Pradaxa).

- History of having arrhythmias - can interfere with EECP triggering.

- Subject has bleeding diathesis.

- Subject has active thrombophlebitis.

- Subject has severe lower extremity vaso-occlusive disease.

- Subject has a documented aortic aneurysm requiring surgical repair.

- Subject is pregnant.

- Subject with blood pressure higher than 180/110 mmHg.

- Subject with a heart rate more than 120 bpm.

- Subject with high risk of complications from increased venous return.

- Subject with clinically significant valvular disease.

- Subjects with severe vascular disease as established by the Hachinski Ischemic Index.

- Subjects with pacemakers and other metallic implantable devices.