A Study Comparing CoQ10 Levels While Taking 3 Different Statins

Statins are known effectively treat high cholesterol and heart disease. However, statins
may lower endogenous levels of Coenzyme10 (CoQ10). This decrease in CoQ10 levels may be
responsible for side effects such as myalgia.

Previous studies have shown that Pitavastatin may not affect CoQ10 levels as other statins
do, while still lowering cholesterol.

In this study, investigators intend to compare the plasma levels of CoQ10 in patients taking
3 different FDA-approved statins, in equipotent doses.

Inclusion Criteria:

- LDL-C levels of 100-200mg/dl; triglycerides
- Willing to discontinue use of all lipid-altering doses fo medication or supplements
for the duration of the study

Exclusion Criteria:

- LDL-C <100mg/dl or >200mg/dl, Triglycerides >200mg/dl

- History of diabetes mellitus or documented fasting blodo glucose >125mg/dl or HbA1c
>6.4%

- History of coronary artery disease

- history of chrinic renal or hepatic disease

- known sensitivity of intolerance to a statin

- persistent elevated liver enzymes or CPK (>3 x upper normal limit)

- currently taking CoQ10 supplements and unable discontinue for duration of study