Dose Effects of SCF on Calcium Metabolism and GI Microflora in Adolescents

The growing knowledge of non-digestible oligosaccharide (NDO)-related health benefits has led
to the identification of other fermentable carbohydrates which may improve bone balance and
bone health parameters. One such carbohydrate is the corn derivative, soluble corn fiber
(SCF). Already known for its association with improved intestinal health and influence on
colonic microflora content, we have been studying the effects of SCF on calcium absorption
and bone health. First we found that soluble corn fiber (SCF) greatly enhanced calcium
utilization and bone properties in a growing rat model. Results from this study demonstrated
that SCF was capable of increasing bone mineral content, density and bone strength parameters
in 4-week old, male rats. Our study in adolescent boys and girls showed a 12% increase in
calcium absorption after consuming 12 g SCF for 21 days compared to a control period in a
crossover design using a controlled feeding metabolic balance approach. Given these profound
changes on calcium absorption and in bone, a logical next step is to study a dose-response
effect of SCF on calcium absorption, bone turnover, and gut microflora in free-living
adolescents.

Inclusion Criteria:

- Healthy adolescent Caucasian girls between the ages of 12-14. This population has been
chosen because they exhibit higher risk for osteoporosis later in life.

Exclusion Criteria:

- Habitual dietary patterns including less than 550 and greater than 1500 mg Ca per day.
This represents the 5th and 95th percentile of usual intake of girls 9-13 y in the US.

- History of smoking, alcohol use, illegal or non-prescription drug use

- History of disordered calcium or bone metabolism e.g. Paget's disease, hyper or
hypo-calcemia

- History of gastrointestinal diseases (Crohn's, celiac, inflammatory bowel disease)

- History of diseases that affect kidney or liver function.

- Body Mass Index (BMI) less than 5th percentile for age or greater than the 90th
percentile for age

- Having a broken bone within the last 6 months.

- Regular consumption of foods or supplements containing prebiotics or probiotics

- History of pregnancy or use of contraceptives