The Effect of Humidification on Mucus Rheology
| Status: | Completed |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 40 - 90 |
| Updated: | 2/7/2015 |
| Start Date: | July 2012 |
| End Date: | December 2014 |
| Contact: | Jennifer L Bradley, B.A. |
| Email: | jlbradley@vcu.edu |
| Phone: | (804) 628-2793 |
In this study the investigators will collect mucus from mechanical ventilated patients and
patients with COPD to study the effect of temperature and humidity, on the biophysical
properties of the airway mucus. It is hypothesised that changes in inspired gas temperature
and humidity (over time) may affect the biophysical properties of the airway mucus and
reduce the airway's ability to clear mucus, resulting in deleterious clinical affects.
patients with COPD to study the effect of temperature and humidity, on the biophysical
properties of the airway mucus. It is hypothesised that changes in inspired gas temperature
and humidity (over time) may affect the biophysical properties of the airway mucus and
reduce the airway's ability to clear mucus, resulting in deleterious clinical affects.
Expectorated sputum samples are collected and used to measure the biophysical properties of
mucus secretions. The samples are later exposed to different temperatures and humidity
levels during bench experiments.
mucus secretions. The samples are later exposed to different temperatures and humidity
levels during bench experiments.
Mechanically Ventilated Patients
Inclusion Criteria:
Any Subject Mechanically Ventilated and producing sputum.
Exclusion
- None
COPD Group
Inclusion Criteria:
- 40 to 90 years of age suffering from COPD
- History of mucus production
Exclusion Criteria:
- None
We found this trial at
1
site
Virginia Commonwealth University Since our founding as a medical school in 1838, Virginia Commonwealth University...
Click here to add this to my saved trials
