Protocol for High-Risk Assessment, Screening, and Early Detection of Pancreatic Cancer

Inclusion Criteria:

- Patients will be eligible if they have 2 or more relatives with pancreatic cancer and
have a first degree relationship with at least one of the relatives with pancreatic
cancer

- If only 2 family members are affected then both must have had pancreatic cancer
and a first-degree relationship with individual screened

- If there are more than 2 affected individuals on the same side of the family at
least one of the individuals must have a first-degree relationship with the
member being screened

- Patients at least 40 years old or 10 years younger than the youngest affected
individual

- Peutz-Jeghers Syndrome (PJS) patients age>30

- Hereditary pancreatitis patients

- Patients with Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM)

- Patients with BRCA2 mutation and at least one first or second degree relative with
documented pancreatic cancer

- Willingness to undergo (EUS) with possible Fine Needle Aspiration (FNA)

- Willingness to undergo surgical evaluation for abnormal EUS/FNA finding

- Willingness to undergo radiographic evaluation if screening findings are abnormal

Exclusion Criteria:

- Medical contraindications to undergoing endoscopy or obstruction of the GI tract that
precludes passage of the endoscope

- Personal history of pancreatic adenocarcinoma

- Previous partial or complete resection of the pancreas for adenocarcinoma

- Prior partial or total gastrectomy with Billroth II or Roux-en-Y anastamosis

- Previous computed tomography (CT) scan, magnetic resonance imaging/magnetic resonance
cholangiopancreatography (MRI/MRCP) or EUS of the abdomen in the past 3 years

- Coexisting cancer in other organs or acquired immunodeficiency syndrome/human
immunodeficiency virus (AIDS/HIV)

- Life expectancy less than 5 years

- Pregnancy