International Plastic Bronchitis Registry
| Status: | Recruiting |
|---|---|
| Conditions: | Bronchitis, Other Indications |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 3/8/2019 |
| Start Date: | July 2012 |
| End Date: | July 2022 |
| Contact: | Meg Lessard, B.S. |
| Email: | margaret.lessard@vcuhealth.org |
| Phone: | 804-628-3093 |
The purpose of the international plastic bronchitis registry is to understand the natural
course and long term health outcomes of subjects diagnosed with plastic bronchitis due to
different types of casts. This provides essential data for identifying best practices and
treatments. The secondary aim is to understand the structure of casts and mechanism of their
formation.
course and long term health outcomes of subjects diagnosed with plastic bronchitis due to
different types of casts. This provides essential data for identifying best practices and
treatments. The secondary aim is to understand the structure of casts and mechanism of their
formation.
Plastic bronchitis (PB) patients have casts removed during bronchoscopy as part of their
routine care or that they are able to expectorate (cough out) casts naturally. The casts are
normally discarded. Patients that agree to participate in the registry ship the airway casts
and medical history to Dr. Bruce Rubin's Research Laboratory at Virginia Commonwealth
University Richmond Virginia, USA.
The lab evaluates the biopolymer composition and structure of the airway casts by
immunohistochemistry in order to identify microscopic differences between expectorated casts
of subjects with plastic bronchitis and sputum from other populations (cystic
fibrosis,chronic obstructive pulmonary disease , and normal airways). The lab also conducts
in vitro evaluation of clearability, adhesivity, cohesivity, and inflammatory mediator
concentrations to better understand the nature of the disease.
routine care or that they are able to expectorate (cough out) casts naturally. The casts are
normally discarded. Patients that agree to participate in the registry ship the airway casts
and medical history to Dr. Bruce Rubin's Research Laboratory at Virginia Commonwealth
University Richmond Virginia, USA.
The lab evaluates the biopolymer composition and structure of the airway casts by
immunohistochemistry in order to identify microscopic differences between expectorated casts
of subjects with plastic bronchitis and sputum from other populations (cystic
fibrosis,chronic obstructive pulmonary disease , and normal airways). The lab also conducts
in vitro evaluation of clearability, adhesivity, cohesivity, and inflammatory mediator
concentrations to better understand the nature of the disease.
Inclusion Criteria:
- Diagnosed with Plastic bronchitis
We found this trial at
1
site
Richmond, Virginia 23298
(804) 828-0100
Principal Investigator: Bruce k Rubin, MEngr, MD, MBA, FRCPC
Phone: 804-628-3921
Virginia Commonwealth University Since our founding as a medical school in 1838, Virginia Commonwealth University...
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