Green Tea in Breast Cancer Patients
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | May 7, 2008 |
| End Date: | June 6, 2016 |
Green Tea Supplement in Women With Incident Breast Cancer
Prognostic factors for breast cancer beyond stage at diagnosis and tumor characteristics have
not been well studied. Of special interest are lifestyle factors that can be modified by
women after diagnosis to increase disease-free survival. Green tea is rich in polyphenols
consisting primarily of epicatechins, epigallocatechin, epicatechin gallate, and
epigallocatechin gallate (EGCG). The investigators hypothesize that there will be a reduction
in proliferation and/or an increase in apoptosis in association with short-term EGCG
treatment.
not been well studied. Of special interest are lifestyle factors that can be modified by
women after diagnosis to increase disease-free survival. Green tea is rich in polyphenols
consisting primarily of epicatechins, epigallocatechin, epicatechin gallate, and
epigallocatechin gallate (EGCG). The investigators hypothesize that there will be a reduction
in proliferation and/or an increase in apoptosis in association with short-term EGCG
treatment.
Inclusion Criteria:
- Postmenopausal (at least 2 years since last menstrual period) or age 55 or older if
prior hysterectomy
- Non-current (not with past 6 months) user of menopausal hormones
- Mammographic abnormality consistent with any type of incident breast cancer
necessitating a diagnostic biopsy (BIRAD IV(b), (c) or V) will be sufficient to draw
baseline LFT and complete screening questionnaire. Unless the biopsy confirms incident
breast cancer, such subjects will not be included in further research interventions
and they will not serve as EGCG treated or control subjects.
- Diagnosed with incident breast cancer on the diagnostic biopsy is required for
inclusion in the EGCG or control treatment groups.
- Non-green tea drinker (less than monthly) - this criteria does not apply to black tea
or herbal tea
- Provided written informed consent
Exclusion Criteria:
- Green tea drinker (once per month or more)
- History of breast cancer or other cancer including a prior diagnosis of any type of
incident breast cancer.
- Known allergy to tea
- Abnormal liver enzymes (plus or minus 10% of the normal ranges).
We found this trial at
1
site
1441 Eastlake Ave
Los Angeles, California 90033
Los Angeles, California 90033
(323) 865-3000
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
Click here to add this to my saved trials
