Eltrombopag/Boceprevir and Eltrombopag/Telaprevir Drug-Drug Interaction Study In Healthy Adult Subjects

Inclusion Criteria:

- Healthy subjects with no clinically significant abnormality identified by physician
by evaluation of medical history, physical examination, clinical laboratory tests or
electrocardiogram (ECG).

- Able to swallow and retain oral medication.

- Male or female subjects between the ages of 18 to 64 years of age inclusive, at the
time of signing the informed consent.

- Capable of giving written informed consent which includes compliance with the
requirements and restrictions listed in the consent form. Signed informed consent
must be on file prior to screening procedures.

- Body weight >= 50 kilogram (kg) (110 pounds [lbs]) for men and >=45 kg (99 lbs) for
women and body mass index (BMI) of 18.5 to 32.0 kg/ (meters squared) m^2 inclusive.

- Male subjects, who are not surgically sterile, must agree on abstinence or to use a
double barrier method, such as, a condom plus spermicidal agent
(foam/gel/film/cream/suppository). This criterion must be followed from the time of
the first dose of study medication until 14 days after the last dose of medication.

- A female subject is eligible to participate if she is neither pregnant nor lactating,
and falls into one of the following categories: non-childbearing potential including
pre-menopausal females with documented (medical report verification) hysterectomy or
bilateral oophorectomy, or postmenopausal females defined as being amenorrheic for
greater than 1 year and having serum estradiol and follicle stimulating hormone
levels consistent with menopause, child-bearing potential with negative beta human
chorionic gonadotropin (βhCG) test and agrees to comply with recognized non-hormonal
contraceptive methods from screening or at least two weeks prior to first dose
(whichever is earlier) until the follow-up visit. Recognized non-hormonal
contraceptive methods include: complete abstinence from intercourse, two forms of
barrier contraception (e.g. condom with spermicide, or diaphragm with spermicide), or
intrauterine device (IUD).

Exclusion Criteria:

- History of Gilbert's syndrome.

- History of deep vein thrombosis or other thromboembolic event.

- History of thrombocytopenia or bleeding due to abnormal platelet number or function.

- Clotting factor abnormalities associated with hypercoagulability, including Factor V
Leiden, Protein C or Protein S deficiency or antithrombin III deficiency.

- Elevated blood pressure (BP) at screening, Day -1 and at pre-dose (systolic >140 mm
Hg [millimeters of mercury], diastolic >90 mmHg). If the subject's BP is elevated on
the first measurement, complete two additional BP measurements at least 2 minutes
apart and average the three assessments to evaluate this criterion. If averaged BP
exceeds the safety criteria, the subject should be excluded.

- History of atrial fibrillation, mitral valve prolapse, significant heart murmur or
vascular bruit.

- Prolonged QTcF interval at screening, Day 1 and at pre-dose (for females and males
>450 milliseconds [ms]). If the QTcF interval is prolonged on the initial ECG, then
complete two additional ECGs at least 5 minutes apart and take the average QTcF
measurements of all three ECGs to evaluate this criterion. If averaged QTcF exceeds
the safety criteria, the subject should be excluded.

- Female subjects currently receiving hormone replacement therapy (HRT).

- Positive for HIV, hepatitis B virus infection or HCV infection at screening.

- Positive urine drug screen including serum alcohol at screening or pre-dose (Day -1).

- History of alcohol/drug abuse or dependence within 12 months of the study. History of
alcohol consumption in the past six months exceeding 7 units/week for women and 14
units/week for men (where 1 unit = 5 ounces of wine or 12 ounces of beer or 1.5
ounces of hard liquor).

- Urinary cotinine levels indicative of smoking at screening or pre-dose (Day -1).
History of regular use of tobacco- or nicotine-containing products within 6 months
prior to screening.

- Treatment with an investigational drug within 30 days or 5 half-lives (whichever is
longer) preceding the first dose of study medication.

- Exposure to more than four new chemical entities within 12 months prior to the first
dosing day.

- Use of prescription or non-prescription drugs (including aspirin and non-steroidal
anti-inflammatory drugs [NSAIDs]), vitamins, herbal and dietary supplements within 7
days (or 14 days if the drug is a potential enzyme inducer, such as St. John's Wort)
or 5 half-lives (whichever is longer) prior to the first dose of study medication,
unless in the opinion of the investigator and sponsor the medication will not
interfere with the study procedures or compromise subject safety.

- Subjects who have donated plasma within 7 days prior to the screening visit or where
participation in this study would result in donation of blood in excess of 500
milliliters (mL) within a 56-day period.

- History of sensitivity to any of the study medications, or components thereof.