STA-9090 in Patients With Advanced Hepatocellular Cancer

Study treatment is given in 4-week time periods called cycles. Patients will receive ST-9090
once weekly for the first 3 weeks of each cycle and no treatment on the fourth week. STA-9090
will be given by intravenous (IV) infusion. IV infusions occur through an IV catheter (or
tube) placed in the vein. Each infusion will last about 60 minutes.

During each cycles patients will have blood tests, pregnancy test, and EKG. Twenty to thirty
days after the last dose, patients will return for a physical exam, blood tests, urine test,
EKG, and CT or MRI of chest and abdomen.

Inclusion Criteria:

- Histologically or cytologically confirmed hepatocellular carcinoma

- Measurable disease

- Life expectancy greater than 3 months

- ECOG performance status 0 or 1

- BCLC Stage C disease

- Lab values must be within limits outlined in protocol

- Child-Pugh score
- CLIP score 0-3

- Must agree to use adequate contraception

Exclusion Criteria:

- Chemotherapy or radiotherapy within 4 weeks prior to entering study or not recovered
from adverse events due to agents administered more than 4 weeks earlier

- Receiving any other investigational agent

- Known brain metastases unless treated and radiographically and clinically stable
without steroid or anticonvulsant medications for at least 4 weeks prior to first dose
of STA-9090

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to STA-9090

- Surgery, radiotherapy, or lesion ablative procedure to the only area of measurable
disease

- Major surgery within 4 weeks prior to first dose of STA-9090

- Poor venous access for study drug administration or would require a peripheral or
central indwelling catheter for study drug administration

- History of severe allergic or hypersensitivity reactions to excipients (e.g.,
Polyethylene glycol [PE] 300 and Polysorbate 80)

- Baseline QTc > 450 msec or previous history of QT prolongation while taking other
medications

- Ventricular ejection fraction
- Treatment with chronic immunosuppressants

- Uncontrolled intercurrent illness including, but not limited to ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Pregnant or breast-feeding

- History of a different malignancy unless disease-free for at least 5 years and deemed
by the investigator to be at low risk for recurrence.

- HIV-positive individuals on combination antiretroviral therapy