Study Comparing High-Dose Flu Vaccine to Standard Vaccine in Cancer Patients Less Than 65 Receiving Chemotherapy

Inclusion Criteria:

1. 18 years old to less than 65 years old

2. Subjects with malignancy must be receiving chemotherapy

3. Medically stable

4. Able to understand and willingness to sign a written informed consent

5. Able to comply with study procedures

6. Life expectancy of more than 3 months

7. Adequate organ function:

- ANC >1000/mm3

- Platelet >100,000/uL

- Creatinine <2 mg/dL

- AST and ALT <3 times the ULN

Exclusion Criteria:

1. Allergy to eggs

2. Prior allergy to Influenza Vaccine

3. History of Guillain-Barre Syndrome

4. Current febrile illness

5. Other immunosuppressive disease (recipients of solid organ transplant, uncontrolled
HIV)

6. Autologous or Allogenic Stem Cell Transplant with in a year

7. Current immunotherapy or immunochemotherapy in the last 6 months (rituximab or
ofatumumab)