Study of Sulfasalazine in Treating Painful Neuropathy
| Status: | Terminated |
|---|---|
| Conditions: | Diabetic Neuropathy, Neurology, Pain |
| Therapuetic Areas: | Endocrinology, Musculoskeletal, Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/24/2018 |
| Start Date: | May 2013 |
| End Date: | August 10, 2017 |
A Single-center, Randomized, Double-blind Clinical Study to Evaluate the Effect of Sulfasalazine on Painful Neuropathy
The investigators hypothesize that sulfasalazine, an FDA-approved medication for rheumatoid
arthritis and ulcerative colitis, may be beneficial in neuropathic pain conditions. In this
study, the investigators will evaluate whether sulfasalazine improves pain due to painful
peripheral neuropathy.
arthritis and ulcerative colitis, may be beneficial in neuropathic pain conditions. In this
study, the investigators will evaluate whether sulfasalazine improves pain due to painful
peripheral neuropathy.
Inclusion Criteria:
- Painful neuropathy
- Michigan Neuropathy Screening Instrument score of 3 or greater
- no obvious alternative explanation for neuropathy
- average baseline pain > 4/10
Exclusion Criteria:
- other severe pain
- anticipated difficulty weaning off medications
- past or current psychiatric disorder as determined by Mini International
Neuropsychiatric Interview
- medical contraindication to sulfasalazine
- not proficient in English (due to heavy use of questionaires)
- pregnant or breast feeding women
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