A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Subcutaneous Injections of ABT-981 in Patients With Osteoarthritis of the Knee
Status: | Completed |
---|---|
Conditions: | Arthritis, Osteoarthritis (OA) |
Therapuetic Areas: | Rheumatology |
Healthy: | No |
Age Range: | 40 - 70 |
Updated: | 11/22/2017 |
Start Date: | September 2012 |
End Date: | October 2013 |
A Randomized, Double-Blind, Placebo Controlled Study in Patients With Osteoarthritis of the Knee to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of ABT-981
To assess the safety, tolerability and pharmacokinetics of ABT-981 in patients with
osteoarthritis of the knee.
osteoarthritis of the knee.
This is a phase 1, randomized, double-blind, placebo-controlled, multiple ascending dose
study. Thirty-six patients with osteoarthritis of the knee will be selected to participate.
Patients will be randomized to receive either ABT-981 or placebo. ABT-981 or placebo will be
administered as subcutaneous (under the skin) injections in four dosing groups. Subjects will
be administered subcutaneous injections of ABT-981 for up to 8 weeks.
study. Thirty-six patients with osteoarthritis of the knee will be selected to participate.
Patients will be randomized to receive either ABT-981 or placebo. ABT-981 or placebo will be
administered as subcutaneous (under the skin) injections in four dosing groups. Subjects will
be administered subcutaneous injections of ABT-981 for up to 8 weeks.
Inclusion Criteria:
- Adult male or female, 40 to 70 years of age, inclusive.
- History of symptomatic osteoarthritis (OA) of the knee joint for at least 3 months,
with typical Osteoarthritis (OA) symptoms
- Radiographic Osteoarthritis (OA) of Kellgren-Lawrence (K-L) grade 1, 2 or 3
- Patients assessment of Osteoarthritis (OA) pain intensity of the study joint is
between 40 and 80 on the 0 - 100 mm VAS scale
- Other than Osteoarthritis (OA) of the study joint, patient should be in general good
health
Exclusion Criteria:
- Radiographic OA of Kellgren-Lawrence grade 4 or chronic opioid user due to severe knee
OA
- History of allergic reaction or significant sensitivity to any constituents of the
study drug and acetominophen or history of anaphylactic reaction to any agent
- Significant trauma or surgery to the study joint within the last year or arthroscopy
within 6 months, or, scheduled for major surgery to the study joint
- Diagnosis of rheumatoid arthritis, other autoimmune disorders or any arthritis other
than Osteoarthritis (OA) of the knee.
- Any uncontrolled medical illness including unstable treatment or therapy.
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