Sinonasal Gas Exchange Dynamics
| Status: | Completed |
|---|---|
| Conditions: | Sinusitis |
| Therapuetic Areas: | Otolaryngology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | August 2013 |
| End Date: | August 2015 |
Sinonasal Gas Exchange Dynamics The Aerodynamic Theory of the Sinonasal Interface
Sinonasal gas exchange is facilitated by the unique anatomy and topography of the sinonasal
interface that represents a collection of airfoils creating an aerodynamic structure. The
airflow during respiration generates positive and negative pressures that power the gas
exchange between the sinuses and the nose. Major surgical alteration of the interface
reduces the rate and velocity of the exchange. Minimally invasive procedures aimed at
preserving the natural anatomy, topography and aerodynamic configuration of the interface
will have negligible effects on sinonasal gas exchange.
interface that represents a collection of airfoils creating an aerodynamic structure. The
airflow during respiration generates positive and negative pressures that power the gas
exchange between the sinuses and the nose. Major surgical alteration of the interface
reduces the rate and velocity of the exchange. Minimally invasive procedures aimed at
preserving the natural anatomy, topography and aerodynamic configuration of the interface
will have negligible effects on sinonasal gas exchange.
Inclusion Criteria:
- Control:
- normal healthy adult volunteers ages 18-65,
- without allergies by history and allergy test,
- non-smoker,
- not using steroids. Study group 1: adult subjects who had maxillary sinus balloon
sinuplasty (with intact uncinate and ethmoid complex) Study group 2: adult subjects
who had endoscopic maxillary antrostomy and uncinectomy.
Exclusion criteria:
- active acute or chronic infection,
- nasal polyps,
- severe nasal or septal deformity,
- cystic fibrosis,
- systemic illness (diabetes, hypertension etc.),
- vulnerable population (children, pregnant women, institutionalized individuals etc.)
- severe nasal and/or septal deviation,
- hypersensitivity or intolerance to study medications (topical and local anesthetics)
any turbinate surgery.
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