Sucrose Breath Test to Determine Intestinal Permeability in IBS
| Status: | Completed |
|---|---|
| Conditions: | Irritable Bowel Syndrome (IBS) |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/1/2014 |
| Start Date: | October 2012 |
| End Date: | January 2013 |
| Contact: | David A Wagner, PhD |
| Email: | david@metsol.com |
| Phone: | 6035986960 |
The Use of a Novel 13C Sucrose Breath Test (13C SBT) to Determine Intestinal Permeability in Irritable Bowel Syndrome (IBS) Patients
Irritable Bowel Syndrome (IBS) is a growing clinical diagnosis affecting 10-20% of the US
population. While current diagnostic criteria aids in correctly diagnosing IBS, the cause of
the disease still remains unclear. It has been hypothesized that patients with IBS have
alterations in the intestinal lining leading to release of toxic substances into the blood,
commonly referred to as leaky gut. Current methods used to study leaky gut are both
expensive and invasive. The investigators will test a new breath test to measure leaky gut
in both IBS patients and subjects without IBS symptoms.
population. While current diagnostic criteria aids in correctly diagnosing IBS, the cause of
the disease still remains unclear. It has been hypothesized that patients with IBS have
alterations in the intestinal lining leading to release of toxic substances into the blood,
commonly referred to as leaky gut. Current methods used to study leaky gut are both
expensive and invasive. The investigators will test a new breath test to measure leaky gut
in both IBS patients and subjects without IBS symptoms.
The sucrose breath test involves taking by mouth 20 grams of common sucrose. This amount of
sucrose is about 4 packets of sugar that you would use to sweeten a beverage. If subjects
meet eligibility criteria, a single breath test will be conducted on all subjects. The
breath test involves collecting breath by exhaling through a straw into a special test tube.
A breath sample is collected before administration of sucrose. After the baseline breath
sample, a sugar solution with the 20 grams of sucrose is administered by mouth. Three
additional breath samples are collected at 30, 60 and 90 minutes. After 90 minutes, the
protocol is finished. We will be analyzing breath carbon dioxide for different levels of
heavy carbon atoms (carbon-13)with an instrument called an isotope ratio mass spectrometer.
Our study plan is to compare the amount of carbon-13 in breath between IBS patients and
subjects without the condition. Up to 20 subjects per group will be studied.
sucrose is about 4 packets of sugar that you would use to sweeten a beverage. If subjects
meet eligibility criteria, a single breath test will be conducted on all subjects. The
breath test involves collecting breath by exhaling through a straw into a special test tube.
A breath sample is collected before administration of sucrose. After the baseline breath
sample, a sugar solution with the 20 grams of sucrose is administered by mouth. Three
additional breath samples are collected at 30, 60 and 90 minutes. After 90 minutes, the
protocol is finished. We will be analyzing breath carbon dioxide for different levels of
heavy carbon atoms (carbon-13)with an instrument called an isotope ratio mass spectrometer.
Our study plan is to compare the amount of carbon-13 in breath between IBS patients and
subjects without the condition. Up to 20 subjects per group will be studied.
Inclusion Criteria:
- Male or females with clinical diagnosis of Irritable Bowel Syndrome by Rome III
criteria (IBS Group) or healthy control.
- Must be 18 years old or greater.
- Women of child-bearing potential must have a negative pregnancy test.
Exclusion Criteria:
- Females who are lactating or pregnant.
- Subjects with allergy to sucrose.
- Subjects with other causes of abdominal pain or altered bowel habits such as IBD,
celiac disease, pancreatitis or gastrointestinal bleeding.
- Subjects with a history of diabetes mellitus.
- Subjects with a recent febrile illness (5 days prior to study).
- Subjects that received an investigational drug or device within 30 days prior to
study entry.
- Subjects that do not have the mental capacity to understand the protocol.
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