A Neurocognitive Model of Anorexia Nervosa

Patients with Anorexia Nervosa (AN) have extreme difficulty changing their eating behavior,
even when they express desire for change. These behaviors seem to override all other
potential responses, and can appear perseverative, or habitual. The purpose of this study is
to investigate thought processes and neural mechanisms that may contribute to the
development of habitual behaviors. The investigators hypothesize that patients with AN will
perform differently than people without eating disorders on a series of neuropsychological
tasks and will show different neural activation patterns in functional neuroimaging scans.

Inclusion:

- DSM-IV-TR™ diagnosis of anorexia nervosa (restricting or binge-purge subtype),
current or prior;

- Age 16-45;

- Inpatient on GCRU

- Medically stable.

Exclusion:

- Any other current major Axis I disorder (including current bulimia nervosa), except
major depression;

- History of concussion, seizure disorder, or other neurological illness;

- History of learning disability;

- Acute Suicidality

Healthy comparison group:

Inclusion:

- No current or past psychiatric illness;

- Age 16-45

- No history of binge eating or vomiting;

- Normal weight (80%-120% ideal body weight)

Exclusion:

- Significant medical or neurologic illness(concussion, seizure disorder, learning
disability, other neurological illness)

- Current psychotropic medication or medications known to impact cognition

Additional Exclusion Criteria for fMRI:

- Significant Claustrophobia

- Pregnancy

- Indwelling metallic object, non-removable metal jewelry, medicinal patch or recent
metallic ink tattoo

- For patients, current psychotropic medications (antidepressants for 2 week (prozac
and antipsychotics for 4 weeks)

- For patients, any other current Axis I diagnosis