Multiple Dose Study of Aducanumab (BIIB037) (Recombinant, Fully Human Anti-Aβ IgG1 mAb) in Participants With Prodromal or Mild Alzheimer's Disease

The study consists of a placebo-controlled period to study week 54, followed by a long-term
extension to study week 518. The placebo-controlled period is conducted with a staggered,
parallel group design, with the first 3 treatment arms conducted in parallel, 2 further
treatment arms subsequently beginning in parallel, 2 additional treatment arms beginning in
parallel, and the last 2 treatment arms subsequently beginning in parallel. Qualifying
participants can enter the long-term extension period for up to 42 additional doses of active
drug for the first 3 years of LTE. Furthermore, up until the last participant in Arms 8 and 9
has had his or her last dose in the fifth year of the LTE, eligible participants will be able
to continue treatment beyond the third year of the LTE.

Key Inclusion Criteria:

- Participants must be ambulatory.

- Participants must meet the following core clinical criteria as determined by the
Investigator:

Prodromal Alzheimer's Disease (AD) (all of the criteria must apply):

- Mini Mental State Examination (MMSE) scores between 24-30 (inclusive)

- a spontaneous memory complaint

- objective memory loss defined as a free recall score of ≤27 on the Free and Cued
Selective Reminding Test (FCSRT)

- a global Clinical Dementia Rating Scale (CDR) score of 0.5

- absence of significant levels of impairment in other cognitive domains

- essentially preserved activities of daily living, and an absence of dementia. OR

Mild Alzheimer's Disease (AD) criteria (all criteria must apply):

- Mini Mental State Examination (MMSE) scores between 20-26 (inclusive)

- a global Clinical Dementia Rating Scale (CDR) of 0.5 or 1.0

- meeting the National Institute on Aging-Alzheimer's Association core clinical criteria
for probable AD.

- Participants must have a positive florbetapir positron emission tomography (PET)
amyloid scan.

- Participants must consent to apolipoprotein E (ApoE) genotyping.

- Apart from clinical diagnosis of Alzheimer's Disease (AD), participant must be in good
health.

- Must have a reliable informant or caregiver.

Key Exclusion Criteria:

- Any medical or neurological condition (other than Alzheimer's Disease) that might be a
contributing cause of the participant's cognitive impairment.

- Have had a stroke or Transient Ischemic Attack (TIA) or unexplained loss of
consciousness in the past 1 year.

- Clinically significant psychiatric illness in past 6 months.

- Seizure in the past 3 years.

- Poorly controlled diabetes mellitus.

- History of unstable angina, myocardial infarction, chronic heart failure, or clinical
significant conduction abnormalities within 1 year prior to Screening.

- Indication of impaired renal or liver function.

- Have human immunodeficiency virus (HIV) infection.

- Have a significant systematic illness or infection in past 30 days.

- Brain MRI showing evidence of acute or sub-acute micro or macrohemorrhage, greater
than 4 microhemorrhages, cortical infarct or greater than one 1 lunar infarct.

- Any contraindications to brain MRI or positron emission tomography (PET) scans.

- Negative positron emission tomography (PET) scan with any amyloid-targeting ligand
within 48 weeks of Screening.

- Clinically significant 12-lead electrocardiogram (ECG) abnormalities.

- Alcohol or substance abuse in past 1 year.

- Taking blood thinners (except for aspirin at a prophylactic dose or less)

- Have changes in medications or doses of medication in past 4 weeks.

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.