Tablet vs. Liquid Suspension Ibuprofen in the Relief of Pain
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Other Indications |
| Therapuetic Areas: | Oncology, Other |
| Healthy: | No |
| Age Range: | 12 - 65 |
| Updated: | 4/2/2016 |
| Start Date: | September 2013 |
| End Date: | May 2015 |
| Contact: | Nancy Robak, RN, MPH |
| Email: | RobakN@mail.amc.edu |
| Phone: | 518-262-3773 |
Ibuprofen (also known as Advil or Motrin) is a medication that is known to reduce pain. It
is also known that ibuprofen levels in the blood rise higher and faster if the medication is
taken in liquid suspension. This study will attempt to determine if ibuprofen suspended in a
liquid works to relieve sore throat pain faster than pills of ibuprofen. It will also
determine whether patients with sore throat prefer to take pill or liquid form of the
medication.
is also known that ibuprofen levels in the blood rise higher and faster if the medication is
taken in liquid suspension. This study will attempt to determine if ibuprofen suspended in a
liquid works to relieve sore throat pain faster than pills of ibuprofen. It will also
determine whether patients with sore throat prefer to take pill or liquid form of the
medication.
Pain is a common emergency and urgent care complaint. Ibuprofen is known to be an effective
treatment for many forms of pain. Sore throat has been established to be an acceptable model
of analgesic effect, and ibuprofen has been found to offer relief in studies of sore throat.
Several studies have demonstrated that ibuprofen in suspension is absorbed into the system
more quickly and results in earlier maximum blood concentrations. To date, no study has
evaluated onset to analgesia as reported by the patient for suspension versus tablet
formation of ibuprofen in an emergency department population presenting with complaints of
sore throat. This is a double blinded randomized placebo controlled trial to compare
suspension versus tablet ibuprofen in an emergency department population presenting with
sore throat. The purpose of this study is to assess whether ibuprofen in suspension form
results in relief of pain more quickly than the tablet form of an equivalent dose of
ibuprofen. We will also determine if there is an interval difference from time of analgesia
administration to perception of analgesia that is clinically significant.
treatment for many forms of pain. Sore throat has been established to be an acceptable model
of analgesic effect, and ibuprofen has been found to offer relief in studies of sore throat.
Several studies have demonstrated that ibuprofen in suspension is absorbed into the system
more quickly and results in earlier maximum blood concentrations. To date, no study has
evaluated onset to analgesia as reported by the patient for suspension versus tablet
formation of ibuprofen in an emergency department population presenting with complaints of
sore throat. This is a double blinded randomized placebo controlled trial to compare
suspension versus tablet ibuprofen in an emergency department population presenting with
sore throat. The purpose of this study is to assess whether ibuprofen in suspension form
results in relief of pain more quickly than the tablet form of an equivalent dose of
ibuprofen. We will also determine if there is an interval difference from time of analgesia
administration to perception of analgesia that is clinically significant.
Inclusion Criteria:
- Age greater than 12 years and less than 65 years
- Weight > 40 kg
- a provider order for ibuprofen to address pharyngitis pain.
- Initial Numeric Pain Score > 6
Exclusion Criteria:
- Known allergy or hypersensitivity to aspirin or NSAIDs
- Inability to swallow pills
- Inability to carry out informed consent in English
- Inability to complete a visual analog pain scale
- A concomitant order for another class of analgesic
- Use of analgesic within 8 hours
- Known 3rd trimester pregnancy
- Significant medical conditions where participation would pose an unnecessary barrier
to ongoing care.
- Those taking opioid medications for more than 3 days
- Weight < 40 kg
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