Efficacy and Safety of GLYX-13 in Subjects With Inadequate/Partial Response to Antidepressants

To evaluate the mean difference in Hamilton Depression Rating Scale 17 (HDRS-17) score for
the combined GLYX-13 mean change versus the placebo group mean change at the end of a 6 week
randomized withdrawal phase (predose baseline score - score at end of randomized withdrawal
period).

Inclusion Criteria:

- Male and female subjects

- Aged 18 to 65 years

- Meets DSM-IV-TR) criteria for major depressive disorder (MDD)

- Current episode has lasted ≥ 8 weeks before Screening with an inadequate response to
all approved antidepressant agent(s) administered at an adequate dose and duration
for the current episode

- Taking no antidepressant agent currently or taking an SSRI or SNRI

- HDRS-17 score ≥ 18 at screening and predose baseline

- Female subjects of childbearing potential with a negative serum pregnancy test prior
to entry into the study and who are practicing an adequate method of birth control
and who do not plan to become pregnant during the course of the study.

- Clinical laboratory values < 2 times the upper limit of normal (ULN) or deemed not
clinically significant per the investigator and Naurex medical monitor

- Ability to understand the requirements of the study, provide written informed
consent, abide by the study restrictions, and agree to return for the required
assessments

- Based on the investigator and Naurex medical monitor's clinical judgment, subjects
with eating disorders, obsessive compulsive disorder (OCD), panic disorder,
post-traumatic stress disorder (PTSD), and generalized anxiety disorders secondary to
major depressive episodes (MDEs) are permitted.

Exclusion Criteria:

- Axis I diagnosis of delirium, dementia, dysthymia, amnestic or other cognitive
disorder, schizophrenia or other psychotic disorder, bipolar I or II disorder, eating
disorder (anorexia or bulimia nervosa), obsessive-compulsive disorder, panic
disorder, acute stress disorder, agoraphobia, social phobia, attention-deficit
hyperactivity disorder (ADHD), or PTSD

- A clinically significant current Axis II diagnosis of borderline, antisocial,
paranoid, schizoid, schizotypal, or histrionic personality disorder

- Experiencing hallucinations, delusions, or any psychotic symptomatology in the
current episode; lifetime history of psychosis

- Huntington's, Parkinson's, Alzheimer's, Multiple Sclerosis, or a history of seizures
or strokes

- Currently hospitalized or residing in an in-patient facility during the study
participation

- Substance abuse within the last 12 months

- Women who are planning to become pregnant during the course of the study

- Allergy or intolerance to current antidepressant or other current medications

- Participation in any clinical trial of an investigational product or device within 30
days of enrollment in this trial with the exception of GLYX13-C-201.

- Positive screen for drugs of abuse

- Have received electroconvulsive therapy, transcranial magnetic stimulation (TMS), or
vagal nerve stimulation (VNS) for the current depressive episode

- Pose current (past 6 months) suicide risk based on administration of the C SSRS and
the investigator's clinical judgment

- Human immunodeficiency virus (HIV) infection (based on the HIV-1 & HIV-2 antibody
screen) or other ongoing infectious disease

- Females who are currently pregnant or planning to become pregnant during the course
of the study

- Dextromethorphan or tramadol since these are serotonin uptake inhibitors

- History of allergy, sensitivity, or intolerance to N-methyl-D-aspartate receptor
[NMDAR] ligands