Safety and Efficacy Study of Gevokizumab to Treat Active Non-infectious Uveitis
| Status: | Terminated |
|---|---|
| Conditions: | Cervical Cancer, Ocular |
| Therapuetic Areas: | Oncology, Ophthalmology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2012 |
A Randomized, Double-masked, Placebo-controlled Study of the Safety and Efficacy of Gevokizumab in the Treatment of Active Non-infectious Intermediate, Posterior, or Pan- Uveitis
The purpose of this study is to evaluate the efficacy of gevokizumab in the treatment of
active non-infectious intermediate, posterior, or pan- uveitis.
active non-infectious intermediate, posterior, or pan- uveitis.
Inclusion Criteria:
- Diagnosis of non-infectious intermediate, posterior, or pan- uveitis in at least one
eye
- Active uveitic disease in at least one eye
- Currently on one of the following stable treatment regimens for uveitis: oral
corticosteroids; systemic immunosuppressive medication; a combination of oral
corticosteroids with at least one systemic immunosuppressive medication
- Effective contraceptive measures
Exclusion Criteria:
- Infectious uveitis and masquerade syndromes
- Isolated anterior uveitis
- Contraindication to mydriatics
- History of allergic or anaphylactic reactions to monoclonal antibodies
- Active tuberculosis disease
- History of recurrent infection or predisposition to infection; active ocular
infection
- Pregnant or nursing women
Other protocol-defined inclusion/exclusion criteria may apply
We found this trial at
53
sites
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