The Role of Sleep in the Treatment of Cannabis Use Disorders



Status:Completed
Conditions:Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 55
Updated:10/24/2018
Start Date:September 2012
End Date:July 2018

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Trial Summary
Trial Overview
Inclusion Criteria
The number of people seeking treatment for marijuana-related problems is on the rise, yet
there is no currently accepted medication proven to help them quit. Frequent marijuana users
have reported that they have trouble sleeping when they try to quit, and that the loss of
sleep can lead to relapse. This research is designed to measure the severity of sleep
problems in people as they are trying to quit heavy use of marijuana, and to investigate
whether extended-release zolpidem (Ambien CR®) can improve quit rates among people trying to
stop using marijuana.


Inclusion Criteria:

1. Age 18-55 years.

2. Recent problematic use of cannabis

3. Cannabis use impacts sleep

Exclusion Criteria:

1. Dependent on drugs other than cannabis or nicotine, or current Axis I psychiatric
disorder

2. Moderate sleep apnea or periodic limb movement disorder

3. Pregnant, breast feeding, or planning to become pregnant within the next 3 months

4. Current condition associated with severe cognitive/social impairment

5. Allergy to any ingredient in extended-release zolpidem or prior adverse reaction to
zolpidem

6. Current use of drugs that affect metabolism via cytochrome P450 or current illness
resulting in severe hepatic impairment

7. Current use of hypnotic medications
We found this trial at
1
site
Johns Hopkins University
3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Principal Investigator: Ryan Vandrey, PhD
Phone: 410-550-2695
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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Baltimore, MD
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