Belinostat and Yttrium Y 90 Ibritumomab Tiuxetan in Patients W/Relapsed Aggressive B-Cell NHL

PRIMARY OBJECTIVES:

I. To document the complete response rate and overall response for patients with relapsed
aggressive high-risk non-Hodgkin's lymphoma treated with two cycles PXD-101 followed by one
cycle of Zevalin.

SECONDARY OBJECTIVES:

I. To estimate 2-year progression-free survival in patients with relapsed aggressive
high-risk non-Hodgkin's lymphoma treated with two cycles PXD-101 followed by one cycle of
Zevalin.

II. To evaluate the toxicity of two cycles PXD-101 and one cycle of Zevalin in patients with
relapsed aggressive high-risk non-Hodgkin's lymphoma.

OUTLINE:

Patients receive belinostat intravenously (IV) over 30-60 minutes on days 1-5. Treatment with
belinostat repeats every 21 days for 2 courses. Patients then receive rituximab IV on days 1
and either 7, 8, or 9, and yttrium Y 90 ibritumomab tiuxetan IV over 10 minutes on day 50.
Treatment continues in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years and
then every 6 months for 3 years.

Inclusion Criteria:

- Biopsy confirmed, CD20 positive diffuse large B-cell lymphoma, primary mediastinal
b-cell lymphoma, mantel cell lymphoma, transformed indolent lymphoma, high
grade-B-cell lymphoma; AND bone marrow must show =< 20% CD20+ B-cells with >= 15%
cellularity within 42 days of study registration

- Any stage disease

- Patients must have been previously treated:

- >= 3rd line if bone marrow transplant (BMT) candidate OR

- >= 2nd line if not BMT candidate OR

- >= 2nd relapse for BMT candidate OR

- >= 1st relapse for non- BMT candidate

- Must have a diagnostic quality CT scan of the chest, abdomen and pelvis OR baseline
PET-CT scan performed within 28 days prior to registration

- Must have bidimensionally measurable disease with lesions at least 1.5 cm in one
dimension ALL measurable disease must be assessed within 28 days of registration

- To determine prior drug regimens: radiation therapy counts as 1 treatment, BMT
including induction counts as one treatment, radioimmunotherapy is not considered a
chemotherapy regimen, rituximab alone is not considered a treatment; all prior therapy
must have been completed at least 30 days prior to registration; patients should not
have taken valproic acid, or any other histone deacetylase inhibitor (eg., vorinostat,
romidepsin), for at least 30 days prior to registration; patients must have recovered
from any toxicities related to therapies prior to registration

- No clinical evidence of CNS involvement by lymphoma, any lab (eg., LDH or radiographic
tests performed to access CNS involvement must be negative and must be performed
within 42 days prior to registration

- Unilateral or bilateral bone marrow biopsy performed within 42 days prior to
registration

- Life expectancy of greater than 3 months

- Karnofsky performance status >= 60%

- Leukocytes >= 3,000/mcL

- Absolute neutrophil count >= 1,500/mcL

- Platelets >= 100,000/mcL

- AST (SGOT)/ALT(SGPT) =< 2.5 X institutional upper limit of normal

- Total bilirubin =< 1.5 X institutional upper limit of normal (unless associated with
Gilbert's syndrome)

- Serum creatinine < 2 x institutional upper limit of normal OR

- Measured creatinine clearance >= 60 mL/min

- LDH < 1.50 X institutional upper limit of normal

- EKG with no significant abnormalities within 28 days prior to registration

- Women of child-bearing potential and men must agree to use adequate contraception

Exclusion Criteria:

- Patients who have had chemotherapy or radiotherapy within 30 days (6 weeks for
nitrosoureas or mitomycin C) prior to study screening or those who have not recovered
from adverse events due to agents administered more than 4 weeks earlier

- Prior radioimmunotherapy

- Pregnant or nursing

- Clinical evidence of CNS involvement by lymphoma

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to PXD-101 or Zevalin or other agents used in the study

- Concomitant medication that may cause Torsade de Pointes, i.e. prolongation of the QT
interval > 500 msec

- Significant cardiovascular disease including unstable angina pectoris, uncontrolled
hypertension, congestive heart failure related to primary cardiac disease, any
condition requiring anti-arrhythmic therapy, ischemic or valvular heart disease, or a
myocardial infarction within the past 6 months

- Current long QT syndrome or baseline prolongation of QT/QTcF interval, i.e.
demonstration of a QTcF interval > 450 msec

- Clinical evidence of severe peripheral vascular disease, diabetic ulcers or venous
stasis ulcers, or history of deep venous or arterial thrombosis within 3 months prior
to screening

- Known to be human immunodeficiency virus (HIV) positive or with known acquired
immunodeficiency syndrome (AIDS) syndrome

- Patients may not be receiving any other investigational agents