Genetic Predictors of Renal Dysfunction Following Heart Transplantation



Status:Active, not recruiting
Conditions:Renal Impairment / Chronic Kidney Disease, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases, Nephrology / Urology
Healthy:No
Age Range:18 - 90
Updated:12/29/2018
Start Date:August 2012
End Date:December 2021

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Trial Summary
Trial Overview
Inclusion Criteria

Pharmacogenomics of Calcineurin Inhibitor Nephrotoxicity in Cardiac Transplantation

Kidney disease is a common problem after heart transplantation. It may be caused by
anti-rejection medications such as cyclosporine or tacrolimus. However, the reason why some
people develop kidney problems after a heart transplant, but other people do not, is not
fully known. This study plans to learn more about the relationship between a person's genetic
make-up (DNA; deoxyribonucleic acid) and the risk of kidney problems after a heart
transplant. The long-term goal of this research is to identify genetic variations that may
help predict the development of kidney problems after heart transplantation.


Inclusion Criteria:

- cardiac-only transplant

- 18 years of age or older at the time of cardiac transplant

- 1 year or more post-cardiac transplant

- treatment with cyclosporine or tacrolimus following transplant

Exclusion Criteria:

- combined organ transplant

- decisionally impaired

- unable to read or speak English

- unable or unwilling to provide written informed consent
We found this trial at
1
site
University of Colorado Anschutz Medical Campus
13001 E 17th Pl
Aurora, Colorado 80045
(303) 724-5000
Principal Investigator: Christina L Aquilante, Pharm.D.
Phone: 303-724-6126
University of Colorado Anschutz Medical Campus Located in the Denver metro area near the Rocky...
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Aurora, CO
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