Imaging During Surgery in Diagnosing Patients With Prostate, Bladder, or Kidney Cancer

PRIMARY OBJECTIVES:

I. The primary objective of this pilot study is to assess the ability of fluorescent imaging
and photoacoustic imaging (PAI) in a clinical setting to distinguish benign from malignant
tissue.

SECONDARY OBJECTIVES:

I. To qualitatively determine the possible benefit of PAI and fluorescent imaging over
traditional white light imaging.

OUTLINE:

Patients undergo fluorescence imaging and PAI during robot assisted laparoscopic surgery.

Inclusion Criteria:

- Patients must have a pathologic confirmation of prostate cancer, bladder cancer, or
kidney cancer based on previous biopsies or procedures OR a strong concern for a
kidney malignancy based on computed tomography (CT) or magnetic resonance imaging
(MRI) imaging

- Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

- Patients with a surgical history or anatomic variant that would preclude robot
assisted laparoscopic approaches to their surgery (i.e. history of ventral hernia
repair with mesh)

- Patients with medical co-morbidities who cannot tolerate laparoscopic surgery
secondary to intra-abdominal carbon dioxide insufflation

- Patients with documented allergy or adverse drug reaction to indocyanine green or
baseline serum creatinine greater than 1.5 mg/dL