High Dose Preoperative Cholecalciferol Supplementation and Perioperative Vitamin D Status

While vitamin D insufficiency [25(OH)D <30 ng/mL] is common in the general population,
hypovitaminosis D may affect 40-80% of patients in the perioperative setting. Recent evidence
also suggests that surgical stress may be associated with a 40% reduction in circulating
25(OH)D levels when compared to preoperative values. Moreover, the derangement in
perioperative 25(OH)D levels may be sustained for up to 3 months after surgery. This finding
has potential implications regarding modifiable risk factors for surgical site infections
(SSIs), which account for nearly 40% of all nosocomial infections. On aggregate, SSIs result
in 3.7 million extra hospital days per annum and an added burden of $1.6 billion in annual
healthcare costs. A growing body of evidence suggests that robust postoperative immune
function is associated with a lower risk of SSIs. At the same time, vitamin D is increasingly
recognized as a key regulator of the innate and adaptive immune systems. Yet, optimization of
perioperative vitamin D status remains grossly understudied. Although our overarching aim is
to study the impact of vitamin D status on SSIs, the focus of the current investigation is to
determine whether the administration of a "bolus" oral dose of cholecalciferol (vitamin D3)
in the preoperative setting alters vitamin D status in the perioperative setting (compared to
a placebo). The investigators elected to conduct the current study in patients who will
undergo colorectal surgery since these patients are historically at higher risk of developing
SSIs and therefore would be ideal for future investigations.

Inclusion Criteria:

- Men and women;

- 18 years or older;

- Scheduled for elective (non-emergent) colorectal surgery;

- Cleared for anesthesia; and

- Expected to stay overnight following surgery

Exclusion Criteria:

- Scheduled for a purely laparoscopic procedure;

- Diagnosis of a terminal illness and/or in hospice care;

- Inability to sign informed consent;

- Inability to comply with study protocol;

- Intending to start vitamin D supplementation within 30 days of surgery;

- Intending to leave the Boston area during the follow-up period;

- History of renal stones or hypercalcemia;

- Medical conditions that can cause hypercalcemia (e.g. metastatic cancer, sarcoidosis,
myeloma primary hyperparathyroidism)

- History of hypercalcemia

- History of severe anemia (Hematocrit <25%)

- Medications that affect vitamin D metabolism (e.g. anti-epileptics, tuberculosis
medication); and

- Already enrolled or planning to enroll in a research study that would conflict with
full participation in the current study or confound the observation or interpretation
of the study findings