Bone Quality by vQCT and HR-pQCT:Translation to Multi-center Clinical Research
| Status: | Completed |
|---|---|
| Conditions: | Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 65 - 80 |
| Updated: | 5/3/2014 |
| Start Date: | April 2012 |
| End Date: | March 2014 |
| Contact: | isra saeed, MD |
| Email: | isra.saeed@ucsf.edu |
| Phone: | 4153534922 |
Our overarching aim is to set up a procedural, analytic and developmental framework to
establish CT of the central and peripheral skeleton as a clinically useful biomarker for
skeletal strength in the clinical research and ultimately in the clinical setting. To
accomplish this, the investigators will develop and validate phantoms and scanning
procedures to standardize strength and structure measurements between different vQCT
scanners and develop standardized acquisition, analytical, and quality control techniques
for HR-pQCT with an emphasis on optimization for multi-center studies.
establish CT of the central and peripheral skeleton as a clinically useful biomarker for
skeletal strength in the clinical research and ultimately in the clinical setting. To
accomplish this, the investigators will develop and validate phantoms and scanning
procedures to standardize strength and structure measurements between different vQCT
scanners and develop standardized acquisition, analytical, and quality control techniques
for HR-pQCT with an emphasis on optimization for multi-center studies.
The investigators will develop new calibration phantoms to address inter and intra scanner
variability in vQCT and HRpQCT. Phantom sets to evaluate inter-scanner disparity and
determine corrections to apply to in vivo scan data in the multi-center settings. These
methods will be validated in a multi-center phantom study and in a 120 patients
variability in vQCT and HRpQCT. Phantom sets to evaluate inter-scanner disparity and
determine corrections to apply to in vivo scan data in the multi-center settings. These
methods will be validated in a multi-center phantom study and in a 120 patients
Inclusion Criteria:
- Healthy men and women
- must be able to lie down on bed
Exclusion Criteria:
- on wheel chair
- age above 80 years 0r less than 65 years
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