Study to Evaluate the Long Term Efficacy, Safety and Tolerability of Secukinumab in Patients With Rheumatoid Arthritis



Status:Recruiting
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:10/24/2015
Start Date:September 2012
End Date:February 2019
Contact:Novartis Pharmaceuticals
Phone:1-888-669-6682

Use our guide to learn which trials are right for you!

A Four Year Extension Study to Evaluate the Long Term Efficacy, Safety and Tolerability of Secukinumab in Patients With Active Rheumatoid Arthritis

This extension study is designed as a 4-year extension to the phase III (core) study
CAIN457F2309. It aims to provide continuous treatment with secukinumab in pre-filled
syringes (PFS) for subjects with rheumatoid arthritis who completed the phase III study
CAIN457F2309, to obtain further long term efficacy, safety and tolerability information.


Inclusion criteria:

1. Subjects who provide a written, signed and dated informed consent before any study
assessment is performed

2. Subjects must have participated in phase III study CAIN457F2309, must have completed
the entire treatment period and must have received secukinumab during phase III study
(either from start of phase III study or after re-assignment to one of the
secukinumab arms after week 16/24)

3. Subjects who are deemed by the investigator to benefit from continued secukinumab
therapy

Exclusion criteria:

1. Any subject taking other concomitant biologic immunomodulating agent(s) except
secukinumab

2. Any subject who is deemed not to be benefiting from the study drug based upon lack of
improvement or worsening of their symptoms

3. Any subject who continued to receive abatacept after week 16 during the phase III
study CAIN457F2309

Other protocol-defined inclusion/exclusion criteria may apply
We found this trial at
60
sites
Norfolk, Virginia 23507
421
mi
from 43215
Norfolk, VA
Click here to add this to my saved trials
Anniston, Alabama 36207
462
mi
from 43215
Anniston, AL
Click here to add this to my saved trials
Austin, Texas 78759
1065
mi
from 43215
Austin, TX
Click here to add this to my saved trials
Aventura, Florida 33180
982
mi
from 43215
Aventura, FL
Click here to add this to my saved trials
Biloxi, Mississippi 39531
740
mi
from 43215
Biloxi, MS
Click here to add this to my saved trials
Boca Raton, Florida 33486
955
mi
from 43215
Boca Raton, FL
Click here to add this to my saved trials
Boston, Massachusetts 02118
643
mi
from 43215
Boston, MA
Click here to add this to my saved trials
Bowling Green, Kentucky 42101
278
mi
from 43215
Bowling Green, KY
Click here to add this to my saved trials
Bridgeport, Connecticut 06606
521
mi
from 43215
Bridgeport, CT
Click here to add this to my saved trials
Bridgeport, Connecticut 06606
521
mi
from 43215
Bridgeport, CT
Click here to add this to my saved trials
Carrollton, Texas 75010
907
mi
from 43215
Carrollton, TX
Click here to add this to my saved trials
Charleston, South Carolina 29407
525
mi
from 43215
Charleston, SC
Click here to add this to my saved trials
Cincinnati, Ohio 45229
95
mi
from 43215
Cincinnati, OH
Click here to add this to my saved trials
Clarksburg, West Virginia 26301
150
mi
from 43215
Clarksburg, WV
Click here to add this to my saved trials
Coeur d'Alene, Idaho 83814
1749
mi
from 43215
Coeur d'Alene, ID
Click here to add this to my saved trials
Coral Springs, Florida 33065
959
mi
from 43215
Coral Springs, FL
Click here to add this to my saved trials
Dallas, Texas 75216
914
mi
from 43215
Dallas, TX
Click here to add this to my saved trials
Dallas, Texas 75216
914
mi
from 43215
Dallas, TX
Click here to add this to my saved trials
Eagan, Minnesota 55121
616
mi
from 43215
Eagan, MN
Click here to add this to my saved trials
El Cajon, California 92020
1939
mi
from 43215
El Cajon, CA
Click here to add this to my saved trials
Flowood, Mississippi 39232
660
mi
from 43215
Flowood, MS
Click here to add this to my saved trials
Freemont, California 94538
2088
mi
from 43215
Freemont, CA
Click here to add this to my saved trials
Hamden, Connecticut 06518
538
mi
from 43215
Hamden, CT
Click here to add this to my saved trials
Hialeah, Florida 33012
986
mi
from 43215
Hialeah, FL
Click here to add this to my saved trials
Houston, Texas 77030
995
mi
from 43215
Houston, TX
Click here to add this to my saved trials
Jackson, Tennessee 38305
436
mi
from 43215
Jackson, TN
Click here to add this to my saved trials
Kansas City, Missouri 64111
619
mi
from 43215
Kansas City, MO
Click here to add this to my saved trials
Kingsport, Tennessee 37660
237
mi
from 43215
Kingsport, TN
Click here to add this to my saved trials
Lansing, Michigan 48910
204
mi
from 43215
Lansing, MI
Click here to add this to my saved trials
Leander, Texas 78641
1055
mi
from 43215
Leander, TX
Click here to add this to my saved trials
Lexington, Kentucky 40509
154
mi
from 43215
Lexington, KY
Click here to add this to my saved trials
Miami, Florida 33136
993
mi
from 43215
Miami, FL
Click here to add this to my saved trials
Miami, Florida 33136
993
mi
from 43215
Miami, FL
Click here to add this to my saved trials
Michigan City, Indiana 46360
235
mi
from 43215
Michigan City, IN
Click here to add this to my saved trials
Morton Grove, Illinois 60053
286
mi
from 43215
Morton Grove, IL
Click here to add this to my saved trials
230 Park Avenue, 21st Floor
New York, New York 10169
1-888-669-6682)
Novartis Novartis, which was created in 1996 by the merger of the Swiss companies Ciba-Geigy...
481
mi
from 43215
New York, NY
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73104
848
mi
from 43215
Oklahoma City, OK
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73104
848
mi
from 43215
Oklahoma City, OK
Click here to add this to my saved trials
Omaha, Nebraska 68144
691
mi
from 43215
Omaha, NE
Click here to add this to my saved trials
Orlando, Florida 32806
797
mi
from 43215
Orlando, FL
Click here to add this to my saved trials
Palm Harbor, Florida 34684
821
mi
from 43215
Palm Harbor, FL
Click here to add this to my saved trials
Pembroke Pines, Florida 33024
976
mi
from 43215
Pembroke Pines, FL
Click here to add this to my saved trials
Pensacola, Florida 32504
695
mi
from 43215
Pensacola, FL
Click here to add this to my saved trials
Plantation, Florida 33324
970
mi
from 43215
Plantation, FL
Click here to add this to my saved trials
Pomona, California 91767
1944
mi
from 43215
Pomona, CA
Click here to add this to my saved trials
Portland, Oregon 97228
Novartis Novartis, which was created in 1996 by the merger of the Swiss companies Ciba-Geigy...
2028
mi
from 43215
Portland, OR
Click here to add this to my saved trials
Richmond Heights, Missouri 63117
400
mi
from 43215
Richmond Heights, MO
Click here to add this to my saved trials
San Antonio, Texas 78207
Novartis Novartis, which was created in 1996 by the merger of the Swiss companies Ciba-Geigy...
1139
mi
from 43215
San Antonio, TX
Click here to add this to my saved trials
Sarasota, Florida 34239
874
mi
from 43215
Sarasota, FL
Click here to add this to my saved trials
Shreveport, Louisiana 71101
787
mi
from 43215
Shreveport, LA
Click here to add this to my saved trials
Spokane, Washington 99202
1778
mi
from 43215
Spokane, WA
Click here to add this to my saved trials
Springfield, Illinois 62703
350
mi
from 43215
Springfield, IL
Click here to add this to my saved trials
Sugar Land, Texas 77478
1008
mi
from 43215
Sugar Land, TX
Click here to add this to my saved trials
Tampa, Florida 33613
821
mi
from 43215
Tampa, FL
Click here to add this to my saved trials
Upland, California 91786
1940
mi
from 43215
Upland, CA
Click here to add this to my saved trials
Van Nuys, California 91405
1979
mi
from 43215
Van Nuys, CA
Click here to add this to my saved trials
Vestavia, Alabama 35216
497
mi
from 43215
Vestavia, AL
Click here to add this to my saved trials
Waco, Texas 76710
983
mi
from 43215
Waco, TX
Click here to add this to my saved trials
Wichita, Kansas 67207
780
mi
from 43215
Wichita, KS
Click here to add this to my saved trials
Zanesville, Ohio 43701
53
mi
from 43215
Zanesville, OH
Click here to add this to my saved trials