A Study of LY2228820 for Recurrent Ovarian Cancer

Phase 1b is unblinded and will have a small number of participants that will take LY2228820
plus gemcitabine and carboplatin to test the safety of the combination and determine a
recommended dose for the Phase 2 portion.

Phase 2 will be blinded and all study participants will receive carboplatin and gemcitabine.
Participants of one group will receive LY2228820, and the other group will receive placebo.

If the participant achieves at least stable disease, there is a maintenance phase following
the first 6 cycles. The participant will take either LY2228820 or placebo. The participant
will continue therapy until disease progression or other discontinuation criteria are
fulfilled.

Inclusion Criteria:

- Have been diagnosed with ovarian, fallopian tube, or primary peritoneal cancer

- Have been treated one time with a platinum-based chemotherapy and your disease has
come back at least six months after you completed treatment

- Are able to swallow tablets

- Have given written informed consent prior to any study procedures

- Have adequate blood counts, hepatic and renal function

- Have performance status equal to or less than 2 on Eastern Cooperative Oncology Group
(ECOG) scale

- Have negative pregnancy test, and if participant is of child bearing potential must
use birth control while on study and for three months after stopping study drug

Exclusion Criteria:

- Have been previously treated with Gemcitabine for ovarian, fallopian tube or primary
peritoneal cancer

- Are currently enrolled or discontinued less than 14 days from another clinical trial

- Have a history of inflammatory bowel disease (Crohn's disease or ulcerative colitis)

- Have taken certain medications or had grapefruit juice within 7 days of initial dose
of study drug, as levels of the study drug may be affected.

- Must not be pregnant or breastfeeding.

- Have malignancy or metastasis of the central nervous system

- Have borderline malignancy