Safety Study of MK-8237 Treatment in House-Dust-Mite Allergic Adolescents (MK-8237-008)

Inclusion Criteria:

- History of physician-diagnosed allergic rhinitis/rhinoconjunctivitis to house dust of
at least 6 months duration (with or without asthma)

- History of controlled asthma for the prior 1 month if participant has asthma, defined
by not exceeding 2 days of symptoms per week; not more than 2 days of albuterol/short
acting beta-agonist [SABA] use per week; and not wakening more than twice a month at
night due to asthma symptoms

- Agrees to remain abstinent or use (or have their partner use) 2 acceptable methods of
birth control from screening and through the duration of the study

Exclusion Criteria:

- Unable to meet medication washout requirements

- History of chronic urticaria and/or chronic angioedema within prior 2 years

- History of anaphylaxis with cardiorespiratory symptoms with prior immunotherapy due
to an unknown cause or to an inhalant allergen

- Unstable, uncontrolled or severe asthma, or has experienced a life-threatening asthma
attack or an occurrence of any clinical deterioration of asthma that resulted in
emergency treatment, hospitalization due to asthma, or treatment with systemic
corticosteroids (but allowing SABAs) at any time within prior 3 months

- History of chronic sinusitis during within prior 2 years

- Pregnant or breast-feeding, or expecting to conceive within the projected duration of
the study

- Known history of allergy, hypersensitivity or intolerance to investigational
medicinal products (except for D. pteronyssinus and/or D. farinae) or self-injectable
epinephrine

- Business or personal relationship with investigational site personnel or Sponsor who
is directly involved with the conduct of the trial