Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 1/13/2017 |
| Start Date: | August 2012 |
| End Date: | January 2017 |
Ticagrelor and Adenosine Uptake. Phase II Study Comparing the Effects of Ticagrelor vs Dipyridamole on Adenosine Uptake
The investigators are trying to determine if a single dose of Ticagrelor will increase
delivery of intraarterially-infused adenosine into the forearm interstitium, consistent with
adenosine reuptake blockade.
delivery of intraarterially-infused adenosine into the forearm interstitium, consistent with
adenosine reuptake blockade.
The investigators will compare adenosine interstitial levels using a parallel design study
with three groups of subjects. Forearm interstitial adenosine levels will be measured at
baseline and after intrabrachial infusion of adenosine at two doses. Subjects will then
randomly receive Ticagrelor 180 mg, Dipyridamole 200 mg, or placebo. Two hours later the
investigators will repeat the dialysate collections at baseline and after adenosine
infusions.
with three groups of subjects. Forearm interstitial adenosine levels will be measured at
baseline and after intrabrachial infusion of adenosine at two doses. Subjects will then
randomly receive Ticagrelor 180 mg, Dipyridamole 200 mg, or placebo. Two hours later the
investigators will repeat the dialysate collections at baseline and after adenosine
infusions.
Inclusion Criteria:
1. Subjects will be healthy volunteers, without significant pulmonary, cardiovascular
gastrointestinal, hematological or renal diseases
2. Not taking any regular medications
3. Able to provide signed consent prior to study participation.
Exclusion Criteria:
1. History of asthma
2. Pregnancy
3. Exposure to an investigational drug in the last 2 months.
4. Known hypersensitivity to study medications
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