A Trial of Cranberry Capsules for Urinary Tract Infection Prevention in Nursing Home Residents



Status:Completed
Conditions:Urology
Therapuetic Areas:Nephrology / Urology
Healthy:No
Age Range:65 - Any
Updated:1/31/2018
Start Date:August 2012
End Date:October 2015

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A Randomized, Controlled Trial of Cranberry Capsules for UTI Prevention in Nursing Home Residents

Urinary tract infection (UTI) is the most common infection in nursing home residents, and
bacteriuria is the greatest trigger for antimicrobial therapy in the nursing home setting.
The primary aim of this study is to test the efficacy of two oral cranberry capsules per day
in the reduction of bacteriuria plus pyuria in female nursing home residents. These aims will
be accomplished by conducting a double blind randomized placebo controlled efficacy trial of
two oral cranberry capsules daily versus placebo in a cohort of Connecticut female nursing
home residents.


Inclusion Criteria:

1. female residents;

2. long term residents

3. English speaking; and

4. age ≥ 65 years.

Exclusion Criteria:

1. residents that are not expected to be in the nursing home for at least one month
(i.e., short term rehabilitation, pending discharge, terminal [life expectancy < 1
month]);

2. residents who are on chronic suppressive antibiotic or anti-infective (i.e.,
mandelamine) therapy for recurrent UTI;

3. residents with end stage renal disease on dialysis (they do not regularly produce
urine);

4. residents unable to produce a baseline clean catch urine specimen for collection;

5. residents on warfarin therapy because of a potential interaction of warfarin and
cranberry juice;

6. residents with a history of nephrolithiasis because cranberry may increase the risk of
nephrolithiasis;

7. have an indwelling bladder catheter in place;

8. have an allergy to cranberry products;

9. are being treated with cranberry products;

10. residence <4 weeks.
We found this trial at
21
sites
Branford, Connecticut 06405
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Branford, CT
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Bridgeport, Connecticut 06606
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Bridgeport, CT
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Bridgeport, Connecticut 06610
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Bridgeport, CT
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267 Grant Street
Bridgeport, Connecticut 06610
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Bridgeport, CT
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East Hartford, Connecticut 06108
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East Hartford, CT
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Fairfield, Connecticut 06825
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Fairfield, CT
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Glastonbury, Connecticut 06033
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Glastonbury, CT
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Greenwich, Connecticut 06830
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Greenwich, CT
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Hamden, Connecticut 06514
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Hamden, CT
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Hamden, Connecticut 06514
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Hamden, CT
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Hartford, Connecticut 06106
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Hartford, CT
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Middletown, CT
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Middletown, Connecticut 06457
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Middletown, CT
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New Haven, Connecticut 06519
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New Haven, CT
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New Haven, Connecticut 06511
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New Haven, CT
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New Haven, Connecticut 06511
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New Haven, CT
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Seymour, Connecticut 06483
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Seymour, CT
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Stratford, CT
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Wallingford, Connecticut 06492
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Wallingford, CT
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Waterbury, Connecticut 06702
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Waterbury, CT
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West Hartford, Connecticut 06119
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West Hartford, CT
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