Free Fatty Acid Metabolite Biomarkers for Cancer
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer, Lung Cancer, Prostate Cancer, Colorectal Cancer, Cancer, Cancer, Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/2/2016 |
| Start Date: | August 2012 |
| End Date: | August 2015 |
| Contact: | Daniel Sessler, M.D. |
| Email: | ds@or.org |
| Phone: | 216-444-4900 |
Surgical removal of tumor at an early stage remains the primary treatment for most cancers.
However, there is currently no reliable screening blood test for detection of lung, colon,
or breast cancer. The Specific Aims are to: 1) assess the diagnostic accuracy of six FFA
metabolites to detect lung and colon cancer in surgical patients; 2)determine the rate and
extent to which FFA metabolites decrease over time after surgery for lung and colon cancer;
and, 3)determine the positive and negative predictive values and overall test accuracy for
diagnostic prostate and breast biopsies.
However, there is currently no reliable screening blood test for detection of lung, colon,
or breast cancer. The Specific Aims are to: 1) assess the diagnostic accuracy of six FFA
metabolites to detect lung and colon cancer in surgical patients; 2)determine the rate and
extent to which FFA metabolites decrease over time after surgery for lung and colon cancer;
and, 3)determine the positive and negative predictive values and overall test accuracy for
diagnostic prostate and breast biopsies.
Inclusion Criteria:
- potential breast cancer
- patients who have early stages of breast cancer prior to surgery potential prostate
cancer lung cancer colon cancer
Exclusion Criteria:
- 1) Patients will be excluded from enrollment if they have severe liver disease (ALT
three times the upper limit of normal). Patients will also be excluded who have taken
aspirin or COX inhibitors within 48 hours of surgery. 2) Patients will be excluded if
a pathologic diagnosis is already available,from a previous needle biopsy
(coordinator will remain blinded). 3) Patients will be excluded have received
pre-procedure chemotherapy or radiotherapy
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