Gemcitabine/Abraxane Chemotherapy and Dose Escalated Radiotherapy for Locally Advanced, Unresectable Pancreatic Cancer

The long term goal is to improve survival of patients with unresectable pancreatic cancer.
Additional potential benefits include increased probability of local control and decreased
distant metastases.

Inclusion Criteria:

- Histologically or cytologically proven carcinoma of the pancreas that is locally
advanced

- ECOG performance status 0- 2

- Adequate labs

- No prior abdominal radiation therapy

- No other concurrent clinically evident malignancy, except inactive nonmelanoma skin
cancer, inactive cervical cancer, or other cancer for which the patient has been
disease-free for 5 years

- All disease must be encompassed within a radiotherapy portal

- Not pregnant or nursing

Exclusion Criteria:

- Patient has metastatic disease on radiological staging

- systemic therapy.

- Patient has known active infection with HIV, hepatitis C or hepatitis B

- Patient has serious medical risk factors involving any of the major organ systems
such that the Investigator considers it unsafe for the patient to receive an
experimental research drug.

- Patient is deemed to be have obvious resectable disease at presentation

- Received any investigational agent within a month prior to enrollment.

- Neuroendocrine tumors of the pancreas