Multiple Dose-escalation Study of AMA0076 in Patients With Ocular Hypertension or Primary Open-angle Glaucoma

Inclusion Criteria include:

1. Adults 30-85 years of age

2. Diagnosis of either ocular hypertension or primary open-angle glaucoma in both eyes

3. Not receiving medication for IOP, or able to stop such medication for a washout
period and the duration of the study without significant risk of adverse consequences
related to glaucomatous disease

4. Elevated IOP (≥ 24 and ≤ 34 mm Hg at 8 AM and ≥ 21 and ≤ 34 mm Hg at 10 AM on
Screening Two visit and Baseline visit in one or both eyes off treatment

Exclusion Criteria include:

1. Uncontrolled intraocular hypertension defined as >34 mm Hg at either of the
screening/baseline visits (after a washout phase in those subjects who were currently
receiving ocular hypotensive therapy).

2. Receiving more than one medication for IOP at time of screening.

3. Central corneal thickness of less than 500 µm or greater than 620 µm.

4. BCVA worse than 20/200 in either eye

5. Significant visual field loss (ie, mean deviation > 10 db or field loss within 10
degrees of fixation), a new field defect, or progression of an existing field defect
in either eye during the year preceding the study.

6. Acute angle-closure glaucoma or appositional or very narrow anterior chamber angle in
either eye.