ABLATE Post Approval Study - Synergy Ablation Lesions for Non-Paroxysmal AF

This prospective, open label, multi-center, observational, single arm registry is designed to
monitor the AtriCure Synergy Ablation System continued safety and efficacy during the
peri-procedural and long-term phase during commercial use in patients being treated for
non-paroxysmal forms of atrial fibrillation who are undergoing a concomitant open, on-pump
cardiac surgical procedure.

Inclusion Criteria:

- Age > or equal to 18 years of age

- History of non-paroxysmal form of AF as defined by the HRS/EHRA/ECAS Consensus
Statement:

- Persistent AF shall be defined as continuous AF that is sustained beyond seven
days. Episodes of AF in which a decision is made to electrically or
pharmacologically cardiovert the patient after greater than or equal to 48 hours
of AF but prior to 7 days, should also be classified as persistent AF episodes.

- Longstanding persistent AF shall be defined as continuous AF of greater than 12
months duration. The performance of a successful cardioversion (sinus rhythm >30
seconds) within 12 months of an ablation procedure with documented early
recurrence of AF with 30 days should not alter the classification of AF as
longstanding persistent.

- Subject is scheduled to undergo elective open cardiac surgical procedure(s) to be
performed on cardiopulmonary bypass for one or more of the following: Coronary Artery
Bypass Grafting, Mitral valve repair or replacement, Aortic valve repair or
replacement, Tricuspid valve repair or replacement. In conjunction with these
procedure patent foramen ovale (PFO) or atrial septal defect (ASD) repair are allowed.

- The patient (or their legally authorized representative) agrees to participate in this
study by singing the IRB approved informed consent form.

- Willing and able to return for scheduled follow up visits.

Exclusion Criteria:

- Stand along AF without indication(s) for concomitant cardiac surgery.

- Need for emergent cardiac surgery (i.e., cardiogenic shock).

- Preoperative need for an intra-aortic balloon pump or intravenous inotropes.

- Pregnancy or desire to get pregnant for the duration of the study concomitant surgical
procedure through the thirty six (36) month follow up period).

- Enrolled in another clinical trial that could confound th e results of this study.