Cryoprobe Transbronchial Lung Biopsy in Lung Transplant Patients
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 99 |
| Updated: | 4/21/2016 |
| Start Date: | November 2011 |
| End Date: | September 2015 |
Prospective Controlled Study of Transbronchial Cryoprobe Versus Forceps Biopsy for Acute Rejection in Lung Transplantation
Lung transplant recipients undergo bronchoscopy with biopsies for clinical indications and
for surveillance in the diagnosis of acute rejection using standard transbronchial forceps.
It is recognized that standard forceps biopsies underestimate the presence or degree of
airway rejection due to crush artifact and sample size. Transbronchial cryobiopies have been
shown in the literature to provide larger samples without crush artifact in a safe fashion
in lung cancer patients. The aim of this study is to determine if transbronchial cryobiopsy
is superior to standard transbronchial forceps biopsies in regards to sample size,
architecture and the diagnosis of early rejection in lung transplant recipients which if
discovered earlier may improve survival.
for surveillance in the diagnosis of acute rejection using standard transbronchial forceps.
It is recognized that standard forceps biopsies underestimate the presence or degree of
airway rejection due to crush artifact and sample size. Transbronchial cryobiopies have been
shown in the literature to provide larger samples without crush artifact in a safe fashion
in lung cancer patients. The aim of this study is to determine if transbronchial cryobiopsy
is superior to standard transbronchial forceps biopsies in regards to sample size,
architecture and the diagnosis of early rejection in lung transplant recipients which if
discovered earlier may improve survival.
Inclusion Criteria:
- Individuals referred for either clinically indicated or surveillance flexible
bronchoscopy will be included in the study population
- Age greater than 18 years and having undergone bilateral orthotopic lung
transplantation
Exclusion Criteria:
- Coagulopathy: plts < 50K, INR > 1.5
- FEV1 < 0.8
- Diffuse bullous disease
- Hemodynamic instability
- Severe hypoxemia
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