Functional Applications of Hyperpolarized 129Xe MRI



Status:Terminated
Conditions:Chronic Obstructive Pulmonary Disease, Pulmonary
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - 80
Updated:12/30/2016
Start Date:January 2013
End Date:December 2016

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria
The overall objectives of our study are to determine the capabilities of hyperpolarized
129Xe MRI to measure lung function and its potential to sensitively detect pulmonary disease
and its progression in COPD. We hypothesize that measurement of alveolar surface area,
septal thickness, and capillary transit time measured with hyperpolarized 129Xe will
correlate better with quality of life measures in COPD subjects than traditional diagnostic
measures such as spirometry and Computed Tomography.


Inclusion Criteria:

- Age 18-80

For Healthy nonsmoker subjects:

- No current physician diagnosed medical disease requiring active medication

- No smoking history, defined as less than 100 cigarettes smoked in a lifetime

- Normal spirometry: FEV1/FVC ≥ 0.70, FEV1 ≥ 80% predicted

For Subjects who have participated in the COPDGene Study

- Post-bronchodilator spirometry: FEV1 > 40% predicted

Exclusion Criteria:

- MR contraindications: e.g., electrical implants such as cardiac pacemakers,
ferromagnetic implants such as prostheses, claustrophobia

- Pregnancy or suspected pregnancy

- Use of continuous oxygen

- Use of antibiotics and/or systemic corticosteroids (new prescription or increased
dose) for an exacerbation of lung disease or any lung infection in the past four
weeks

- Uncontrolled cancer, as defined as ongoing radiation therapy, ongoing chemotherapy

- A heart attack in the past three months
We found this trial at
1
site
Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Principal Investigator: Samuel Patz, PhD
Phone: 617-278-0616
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
?
mi
from
Boston, MA
Click here to add this to my saved trials