Consequences of Obstructive Sleep Apnea on Respiratory Function Following Weight-loss Surgery
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies, Obesity Weight Loss, Pulmonary |
| Therapuetic Areas: | Endocrinology, Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | March 2012 |
| End Date: | March 2016 |
Consequences of Obstructive Sleep Apnea on Respiratory Function Following Weight-loss Surgery: A Randomized Controlled Trial
The investigators propose to compare two different treatments, continuous positive airway
pressure (CPAP) versus breathing of atmospheric pressure, in subjects with obstructive sleep
apnea (OSA)recovering from weight loss surgery in the post anesthesia care unit (PACU). WE
hypothesize that subjects with OSA will have a higher Apnea-Hypopnea Index (AHI) with
desaturation and the investigators expect that post-operative CPAP treatment in the PACU
will significantly improve the AHI and therefore improve patient safety in the PACU. The
investigators also hypothesize that subjects with OSA have a greater decrease in oxygen
saturation in response to opioid administration by patient-controlled opioid analgesia
(PCA).
pressure (CPAP) versus breathing of atmospheric pressure, in subjects with obstructive sleep
apnea (OSA)recovering from weight loss surgery in the post anesthesia care unit (PACU). WE
hypothesize that subjects with OSA will have a higher Apnea-Hypopnea Index (AHI) with
desaturation and the investigators expect that post-operative CPAP treatment in the PACU
will significantly improve the AHI and therefore improve patient safety in the PACU. The
investigators also hypothesize that subjects with OSA have a greater decrease in oxygen
saturation in response to opioid administration by patient-controlled opioid analgesia
(PCA).
Patients with morbid obesity have an approximately 60-80 percent incidence of OSA depending
on the criteria used for making diagnosis, and they are suggested to be at increased risk to
develop serious perioperative complications, especially during the postoperative period.
Weight loss might be considered as an appropriate treatment of OSA but in turn it has
recently been reported that OSA is an independent risk factor for development of
perioperative complications, importantly oxygen desaturation, in patients undergoing weight
loss surgery. It seems logical to evaluate if these patients would benefit from
post-operative CPAP treatment in the PACU. The results of this multidisciplinary study will
have an impact on PACU treatment of patients with OSA and will further optimize patient care
at MGH.
on the criteria used for making diagnosis, and they are suggested to be at increased risk to
develop serious perioperative complications, especially during the postoperative period.
Weight loss might be considered as an appropriate treatment of OSA but in turn it has
recently been reported that OSA is an independent risk factor for development of
perioperative complications, importantly oxygen desaturation, in patients undergoing weight
loss surgery. It seems logical to evaluate if these patients would benefit from
post-operative CPAP treatment in the PACU. The results of this multidisciplinary study will
have an impact on PACU treatment of patients with OSA and will further optimize patient care
at MGH.
Inclusion Criteria:
- patients scheduled for weight loss surgery at Massachusetts General Hospital
- Male and female subjects
- age ≥ 18 years
Exclusion Criteria:
- CNS disease with impairment of cognitive function and/or muscle paresis such as
stroke, or dementia
- age < 18 years
- missing or insufficient PSG data to make diagnosis OSA
- impaired decision making capacity
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