Immunogenicity of ND1.1 by Delivery Directly to the Ileum

Inclusion Criteria:

- Able and willing to complete informed consent

- Healthy, as established by medical history, physical exam, and laboratory assessments

- Has normal bowel movements

- Willing to abstain from caffeine and xanthine containing substances for 24 hours
before procedure until after discharge

Exclusion Criteria:

- Ability to donate up to 550 ml of blood over several months

- Exposure to any investigational drug or vaccine 8 weeks prior to study

- Has traveled to Asia within 8 weeks of enrollment

- Abnormal ECG findings

- History of irritable bowl or any other inflammatory gastrointestinal disorder

- Any individual with increased risk for bowl obstruction

- Radiation exposure above target values 50 mSv within the past 30 days or a cumulative
dose above 150 mSv in the past 12 months

- History of substance abuse

- Subject unwilling to use an approved method of contraception during study and for 2
months after study

- Positive for HCV, HIV, or HBV

- Presence of an implantable device that is sensitive to radio frequencies (e.g.
pacemakers)

- History of an autoimmune disorder, or an immunosuppressive disorder

- Stool sample with occult blood at baseline

- Any other medical, psychiatric, social condition, or occupation, in the judgement of
the investigator, is a contraindication to the compliance of the protocol or informed
consent