A Nutrition Intervention for Arthritis -2

Preliminary evidence suggests that low-fat, vegetarian diets and certain nutritional
supplements can help reduce pain and also reduce the need for pain medications for some
people. The investigators will ask about 100 people to participate. All of them will get a
low-fat, vegan diet and a nutritional supplement (mixture of omega-3 oils and vitamin E or a
placebo), although some will get the diet first, and others will get the supplement first.
This order in which they will get the diet and the supplement will be determined randomly,
that is, by chance (like the toss of a coin). The principal measure is pain as measured by
Visual Analog Scale (VAS) and disease activity as measured by number of painful swollen and
tender joints, respectively. The Beck Depression Inventory II (BDI-II)will be used to measure
changes in mood. The study duration is 36 weeks.

Inclusion Criteria:

A diagnosis of rheumatoid arthritis based on 2010 ACR / EULAR Rheumatoid Arthritis
Classification Criteria. Classification as "definite RA" is based on:

- the confirmed presence of synovitis in at least 1 joint

- absence of an alternative diagnosis that better explains the synovitis

- and achievement of a total score of 6 or greater (of a possible 10): 24 Joint
involvement, designating the metacarpophalangeal joints, proximal interphalangeal
joints, the interphalangeal joint of the thumb, second through third
metatarsophalangeal joint and wrist as small joints, and elbows, hip joints and knees
as large joints:

1. Involvement of 1 large joint gives 0 points

2. Involvement of 2-10 large joints gives 1 point

3. Involvement of 1-3 small joints (with or without involvement of large joints)
gives 2 points

4. Involvement of 4-10 small joints (with or without involvement of large joints)
gives 3 points

5. Involvement of more than 10 joints (with involvement of at least 1 small joint)
gives 5 points

- Serological parameters - including the rheumatoid factor as well as anti-citrullinated
protein antibody (ACPA):

1. Negative RF and negative ACPA gives 0 points

2. Low-positive RF or low-positive ACPA gives 2 points

3. High-positive RF or high-positive ACPA gives 3 points Acute phase reactants: 1
point for elevated erythrocyte sedimentation rate (ESR) or elevated C-reactive
protein (CRP) value Duration of arthritis: 1 point for symptoms lasting six weeks
or longer

- Continuing or recurring pain (i.e., joint pain daily, unless on pain medication).

- Age at least 18 years

- Ability and willingness to participate in all components of the study

- Willingness to be assigned to either the diet group or supplement group

- Pain medications unchanged within last 6 weeks.

Exclusion Criteria:

- < 18 years of age

- Rheumatoid arthritis for more than 6 years

- Alcohol consumption of more than 2 drinks per day or the equivalent, episodic
increased drinking (e.g., more than 2 drinks per day on weekends), or a history of
alcohol abuse or dependency followed by any current use

- Use of recreational drugs in the past 6 months (past drug use, if fully recovered, is
not a criteria for exclusion)

- Pregnancy

- Unstable medical or psychiatric illness

- Likely to be disruptive in group sessions (as determined by research staff)

- Already following a low-fat, vegan diet

- Lack of English fluency

- Inability to maintain current medication regimen

- Inability or unwillingness to participate in all components of the study