Effect of Resistance Training on Tobacco-Related Cardiovascular Disease Risk
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Smoking Cessation |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 35 |
| Updated: | 4/2/2016 |
| Start Date: | April 2011 |
| End Date: | December 2013 |
| Contact: | Exercise and Metabolic Disease Laboratory |
| Email: | info@uclaemdr.com |
This project is prompted by the urgent public health need to identify novel strategies to
prevent and treat tobacco-related cardiovascular disease (CVD) and by compelling pilot data
that suggests cessation of smoking results in rapid amelioration of endothelial function.
The higher prevalence of CVD and metabolic syndrome in smokers have become major health care
concerns. Therefore, finding optimal intervention strategies to combat these growing
epidemics is imperative. We are investigating the efficacy of resistance training to
ameliorate endothelial dysfunction, oxidative stress, inflammation, and insulin resistance
in four groups: presence or absence of resistance training with or without cessation
treatment + nicotine replacement.
The investigators hypothesize that resistance training will improve cardiovascular function
in smokers; however, the responses will be better in those who also stop smoking. In
addition, resistance training will decrease smoking, however, the effects of counseling and
nicotine replacement alone or counseling and nicotine replacement in conjunction with
resistance training will be better than resistance training alone.
prevent and treat tobacco-related cardiovascular disease (CVD) and by compelling pilot data
that suggests cessation of smoking results in rapid amelioration of endothelial function.
The higher prevalence of CVD and metabolic syndrome in smokers have become major health care
concerns. Therefore, finding optimal intervention strategies to combat these growing
epidemics is imperative. We are investigating the efficacy of resistance training to
ameliorate endothelial dysfunction, oxidative stress, inflammation, and insulin resistance
in four groups: presence or absence of resistance training with or without cessation
treatment + nicotine replacement.
The investigators hypothesize that resistance training will improve cardiovascular function
in smokers; however, the responses will be better in those who also stop smoking. In
addition, resistance training will decrease smoking, however, the effects of counseling and
nicotine replacement alone or counseling and nicotine replacement in conjunction with
resistance training will be better than resistance training alone.
The investigators are conducting a 12-week randomized-controlled trial of 100 young adult
smokers.
At week 0, participants attend three outpatient visits at baseline. Each participant is
randomized to one of four groups: Resistance Training(RT)/Nicotine Replacement Therapy
(NRT), RT/No NRT, No RT/NRT, and No RT/No NRT. Those receiving RT work with a certified
personal trainer 3 times per week for 12 weeks at 60 minutes each session. Those receiving
NRT use the nicotine patch daily for 12 weeks and call the California Smoker's Helpline for
smoking cessation counseling. Those in the control group do not receive any intervention and
maintain their current lifestyle and habits.
At week 13, participants return for three post-intervention assessments.
At week 26, survey data is collected to assess changes in lifestyle habits.
smokers.
At week 0, participants attend three outpatient visits at baseline. Each participant is
randomized to one of four groups: Resistance Training(RT)/Nicotine Replacement Therapy
(NRT), RT/No NRT, No RT/NRT, and No RT/No NRT. Those receiving RT work with a certified
personal trainer 3 times per week for 12 weeks at 60 minutes each session. Those receiving
NRT use the nicotine patch daily for 12 weeks and call the California Smoker's Helpline for
smoking cessation counseling. Those in the control group do not receive any intervention and
maintain their current lifestyle and habits.
At week 13, participants return for three post-intervention assessments.
At week 26, survey data is collected to assess changes in lifestyle habits.
Inclusion Criteria:
- Young Adults (18-35 yrs.)
- Male and female smokers
- Smokers (smoked at least one cigarette a day for 15 or more days in the last month
and has smoked 100 cigarettes in life)
- 1-3 years experience consistently exercising/training at ≤2 days/wk of RT and ≤1
day/wk of aerobic exercise
- Capable of providing informed consent
- UCLA students/staff and Non UCLA student/staff
- Participant in good health as determined by baseline visit
Exclusion Criteria:
- Documented CAD
- Has had cardiac surgery
- Currently in weight loss or exercise program in the 6 months prior to participation.
- Use of medications that influence CV function or preclude the ability to train
- Syndromes or prescribed medications that may influence CVD, body composition, or
insulin action (e.g. prednisone, Ritalin, Adderall, GH)
- Unable to exercise
- Diagnosed with syndromes or diseases that may influence body composition and CV risk
(e.g. Cushing syndrome).
- Known heart arrhythmia and/or abnormalities found in electrocardiogram (ECG) reading
that would prevent someone from performing the exercise intervention. If the subject
demonstrates abnormal ECG during their pre-intervention visit (or any follow-up
visit) the subject's ECG will be reviewed (for approval) by a cardiologist to
continue in the study.
- Pregnant
- Use of hormonal contraceptives
- Currently in a smoking cessation program including use of NRT within the month of
participation
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