Study to Investigate Prucalopride vs. Polyethylene Glycol 3350 on Colon Activity

Inclusion Criteria:

- Chronic constipation

- Male or female ages 18-75 years

- Non-pregnant, non-lactating female

Exclusion Criteria:

- Drug-induced constipation

- Subjects suffering from secondary causes of chronic constipation, such as:

- Endocrine disorders, e.g. hypopituitarism, hypothyroidism, hypercalcemia,
pseudohypoparathyroidism, pheochromocytoma or glucagon-producing tumors, unless
these are controlled by appropriate medical therapy.

- Metabolic disorders, e.g. porphyria, uremia, hypokalemia or amyloid neuropathy,
unless these are controlled by appropriate medical therapy

- Neurological disorders, e.g. Parkinson's disease, cerebral tumors,
cerebrovascular accidents, multiple sclerosis, meningocele, aganglionosis,
hypoganglionosis, hyperganglionosis, autonomic neuropathy or neuropathy due to
chemotherapy, spinal cord injury, Chaga's disease, or major depression

- Surgery.

- Subjects with insulin-dependent diabetes mellitus

- Rectal evacuation disorder/outlet obstruction

- Subjects with intestinal perforation or obstruction

- Severe renal impairment

- Subjects with a history of alcohol or drug abuse

- Subjects with lactose intolerance

- Subjects with clinically significant cardiac, vascular, liver, pulmonary, endocrine,
neurological or psychiatric disorders