Neurofibromatosis Type 1 Brain Tumor Genetic Risk
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Other Indications, Brain Cancer |
| Therapuetic Areas: | Oncology, Other |
| Healthy: | No |
| Age Range: | Any - 18 |
| Updated: | 5/10/2017 |
| Start Date: | October 2012 |
| End Date: | May 8, 2017 |
Genetic Variation and Risk of Pediatric Brain Cancers
This study will analyze DNA samples to determine associations between maternal and offspring
genetic factors and pediatric brain tumor development in children with Neurofibromatosis
Type 1. Participating families (mother, father, child) will be asked to complete a short
questionnaire and provide DNA samples (either saliva or blood). The information gained from
your participation may one day help doctors develop strategies to reduce brain tumor risk in
individuals with NF1. Please note: there is no therapy associated with this study.
genetic factors and pediatric brain tumor development in children with Neurofibromatosis
Type 1. Participating families (mother, father, child) will be asked to complete a short
questionnaire and provide DNA samples (either saliva or blood). The information gained from
your participation may one day help doctors develop strategies to reduce brain tumor risk in
individuals with NF1. Please note: there is no therapy associated with this study.
The prenatal period is a developmentally vulnerable time point during which environmental
conditions, including nutrition, can have life-long impacts on health.1,2 This is
particularly relevant to many childhood cancers that are thought to initiate during
pregnancy.3 As a consequence, there has been intense interest in whether prenatal exposures
can modulate childhood cancer risk.4-6 It is important to recognize that both maternal and
offspring genetic factors including those in nutritional pathways may play an important role
in pediatric cancer risk through their effect on the child's exposure to nutrients important
in development during the prenatal period. The purpose of this research study is to evaluate
whether there are any maternal or offspring genetic factors in the folate pathway that may
contribute to the development of brain tumors in children with Neurofibromatosis Type 1
through analysis of DNA samples collected from families.
conditions, including nutrition, can have life-long impacts on health.1,2 This is
particularly relevant to many childhood cancers that are thought to initiate during
pregnancy.3 As a consequence, there has been intense interest in whether prenatal exposures
can modulate childhood cancer risk.4-6 It is important to recognize that both maternal and
offspring genetic factors including those in nutritional pathways may play an important role
in pediatric cancer risk through their effect on the child's exposure to nutrients important
in development during the prenatal period. The purpose of this research study is to evaluate
whether there are any maternal or offspring genetic factors in the folate pathway that may
contribute to the development of brain tumors in children with Neurofibromatosis Type 1
through analysis of DNA samples collected from families.
Inclusion Criteria:
- Pediatric participant (born during 1994-2012) with NF1 and diagnosed with a brain
tumor
- Biological mother or father (or full sibling if mother or father is unable to
participate) able to participate
- All family members (pediatric participant, biological mother, and biological father
or full sibling) must be willing to contribute a blood or saliva sample
- ability to understand consent forms
Exclusion Criteria:
-those who do not meet inclusion criteria
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